8ZQE
Cryo-EM structure of the GPR15L(C11)-bound GPR15 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40472.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 97 | 10514.0 | 1 | Pfam (PF00631) UniProt (by SIFTS) (P59768) | Homo sapiens | |
| 4 | D (S) | scFv16 | polymer | 279 | 29786.3 | 1 | Homo sapiens | ||
| 5 | E (R) | GPR15 | polymer | 881 | 98619.4 | 1 | Pfam (PF07361) Pfam (PF00001) Pfam (PF01547) UniProt (by SIFTS) (P0ABE7) UniProt (by SIFTS) (P49685) UniProt (by SIFTS) (P0AEX9) | Homo sapiens | |
| 6 | F (L) | Protein GPR15LG | polymer | 10 | 1065.3 | 1 | UniProt (Q6UWK7) | Homo sapiens | Antimicrobial peptide with 57 amino acid residues,AP-57,Antimicrobial peptide-57,Colon-derived SUSD2 binding factor,CSBF,Protein GPR15 ligand,Protein GPR15L,Secreted protein C10orf99 |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ser 326 | Ala 326 | conflict |
| Leu 343 | Ile 343 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 217874.0 | |
| All* | Total formula weight | 217874.0 |
