8ZQ1

The crystal structure of PDE4D with isoaurostatin derivatives 1-12

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	3',5'-cyclic-AMP phosphodiesterase 4D	polymer	506	57758.4	2	UniProt (Q08499) Pfam (PF18100) Pfam (PF00233)	Homo sapiens (human)	DPDE3,PDE43,cAMP-specific phosphodiesterase 4D
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, G (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E, H (A, B)	(3~{E})-3-[(3,4-dimethoxyphenyl)methylidene]-6-oxidanyl-1-benzofuran-2-one	non-polymer		298.3	2	Chemie (A1D8N)
5	I, J (A, B)	water	water		18.0	156	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	115516.8
Non-Polymers*	Number of molecules	6
	Total formula weight	776.0
All*	Total formula weight	116292.8

*Water molecules are not included.