8ZPP

Local CryoEM structure of the SARS-CoV-2 BA.5 in complex with ORB10 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Spike glycoprotein,Fibritin	polymer	1260	139437.6	1	UniProt (P0DTC2) UniProt (P10104) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein,Collar protein,Whisker antigen control protein
2	B (H)	variable heavy chain of ORB10 Fab	polymer	119	13172.4	1		Mus musculus
3	C (L)	variable light chain of ORB10 Fab	polymer	108	11486.7	1		Mus musculus

Sequence modifications

A: 6 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Ile 24	Thr 19	variant
-	Leu 24	deletion
-	Pro 25	deletion
-	Pro 26	deletion
Ser 29	Ala 27	variant
-	His 69	deletion
-	Val 70	deletion
Asp 142	Gly 142	variant
Gly 213	Val 213	variant
Asp 339	Gly 339	variant
Phe 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ala 376	Thr 376	variant
Asn 405	Asp 405	variant
Ser 408	Arg 408	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Arg 452	Leu 452	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Val 486	Phe 486	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
Gly 614	Asp 614	variant
Tyr 655	His 655	variant
Lys 679	Asn 679	variant
His 681	Pro 681	variant
Gly 682	Arg 682	conflict
Ser 683	Arg 683	conflict
Ser 685	Arg 685	conflict
Lys 764	Asn 764	variant
Tyr 796	Asp 796	variant
Pro 817	Phe 817	conflict
Pro 892	Ala 892	conflict
Pro 899	Ala 899	conflict
Pro 942	Ala 942	conflict
His 954	Gln 954	variant
Lys 969	Asn 969	variant
Pro 986	Lys 986	variant
Pro 987	Val 987	variant
Gly 1209	-	linker
Ser 1210	-	linker

A: 1211 - 1237 (UniProt: P10104)

PDB	External Database	Details
Leu 1232	Phe 479	conflict
Gly 1238	-	expression tag
Arg 1239	-	expression tag
Ser 1240	-	expression tag
Leu 1241	-	expression tag
Glu 1242	-	expression tag
Val 1243	-	expression tag
Leu 1244	-	expression tag
Phe 1245	-	expression tag
Gln 1246	-	expression tag
Gly 1247	-	expression tag
Pro 1248	-	expression tag
Gly 1249	-	expression tag
Gly 1250	-	expression tag
Gly 1251	-	expression tag
Gly 1252	-	expression tag
Gly 1253	-	expression tag
Ser 1254	-	expression tag
Gly 1255	-	expression tag
Gly 1256	-	expression tag
Gly 1257	-	expression tag
Gly 1258	-	expression tag
Ser 1259	-	expression tag
His 1260	-	expression tag
His 1261	-	expression tag
His 1262	-	expression tag
His 1263	-	expression tag
His 1264	-	expression tag
His 1265	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	164096.7
All*	Total formula weight	164096.7

*Water molecules are not included.