8ZPM
Cryo-EM strucutre of CXCR4 complexed with antagonist AMD070
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Soluble cytochrome b562,C-X-C chemokine receptor type 4 | polymer | 486 | 55451.1 | 1 | UniProt (P0ABE7) UniProt (P61073) Pfam (PF12109) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,CXC-R4,CXCR-4,FB22,Fusin,HM89,LCR1,Leukocyte-derived seven transmembrane domain receptor,LESTR,Lipopolysaccharide-associated protein 3,LAP-3,LPS-associated protein 3,NPYRL,Stromal cell-derived factor 1 receptor,SDF-1 receptor |
| 2 | B (N) | Nb6 nanobody | polymer | 169 | 18665.9 | 1 | Lama glama | ||
| 3 | C (R) | (S)-N1-((1H-Benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine | non-polymer | 349.5 | 1 | Chemie (A1D8L) | |||
| 4 | D, E (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) |
Sequence modifications
R: -111 - -7 (UniProt: P0ABE7)
R: 1 - 224 (UniProt: P61073)
R: 249 - 327 (UniProt: P61073)
| PDB | External Database | Details |
|---|---|---|
| Met -137 | - | initiating methionine |
| Lys -136 | - | expression tag |
| Thr -135 | - | expression tag |
| Ile -134 | - | expression tag |
| Ile -133 | - | expression tag |
| Ala -132 | - | expression tag |
| Leu -131 | - | expression tag |
| Ser -130 | - | expression tag |
| Tyr -129 | - | expression tag |
| Ile -128 | - | expression tag |
| Phe -127 | - | expression tag |
| Cys -126 | - | expression tag |
| Leu -125 | - | expression tag |
| Val -124 | - | expression tag |
| Phe -123 | - | expression tag |
| Ala -122 | - | expression tag |
| Asp -121 | - | expression tag |
| Tyr -120 | - | expression tag |
| Lys -119 | - | expression tag |
| Asp -118 | - | expression tag |
| Asp -117 | - | expression tag |
| Asp -116 | - | expression tag |
| Asp -115 | - | expression tag |
| Lys -114 | - | expression tag |
| Gly -113 | - | expression tag |
| Ser -112 | - | expression tag |
| Trp -105 | Met 29 | conflict |
| Ile -10 | His 124 | conflict |
| Leu -6 | - | linker |
| Leu -5 | - | linker |
| Val -4 | - | linker |
| Pro -3 | - | linker |
| Arg -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp 125 | Leu 125 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 225 | - | linker |
| Leu 226 | - | linker |
| Lys 227 | - | linker |
| Ser 228 | - | linker |
| Val 229 | - | linker |
| Arg 230 | - | linker |
| Leu 231 | - | linker |
| Leu 232 | - | linker |
| Ser 233 | - | linker |
| Gly 234 | - | linker |
| Ser 235 | - | linker |
| Arg 236 | - | linker |
| Glu 237 | - | linker |
| Lys 238 | - | linker |
| Asp 239 | - | linker |
| Arg 240 | - | linker |
| Asn 241 | - | linker |
| Leu 242 | - | linker |
| Arg 243 | - | linker |
| Arg 244 | - | linker |
| Ile 245 | - | linker |
| Thr 246 | - | linker |
| Arg 247 | - | linker |
| Pro 248 | - | linker |
| Gly 328 | - | expression tag |
| Arg 329 | - | expression tag |
| Pro 330 | - | expression tag |
| Leu 331 | - | expression tag |
| Glu 332 | - | expression tag |
| Val 333 | - | expression tag |
| Leu 334 | - | expression tag |
| Phe 335 | - | expression tag |
| Gln 336 | - | expression tag |
| Gly 337 | - | expression tag |
| Pro 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
| His 347 | - | expression tag |
| His 348 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74117.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1122.8 | |
| All* | Total formula weight | 75239.7 |
