8ZPM
Cryo-EM strucutre of CXCR4 complexed with antagonist AMD070
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Soluble cytochrome b562,C-X-C chemokine receptor type 4 | polymer | 486 | 55451.1 | 1 | UniProt (P0ABE7) UniProt (P61073) Pfam (PF12109) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,CXC-R4,CXCR-4,FB22,Fusin,HM89,LCR1,Leukocyte-derived seven transmembrane domain receptor,LESTR,Lipopolysaccharide-associated protein 3,LAP-3,LPS-associated protein 3,NPYRL,Stromal cell-derived factor 1 receptor,SDF-1 receptor |
| 2 | B (N) | Nb6 nanobody | polymer | 169 | 18665.9 | 1 | Lama glama | ||
| 3 | C (R) | Mavorixafor | non-polymer | 349.5 | 1 | Chemie (A1D8L) | |||
| 4 | D, E (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (45044259) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) PubChem (176980071) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (44654663) PubChem (46937002) PubChem (59274407) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (304) PubChem (138967089) PubChem (139566851) PubChem (15939944) PubChem (171828367) PubChem (173516975) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) |
Sequence modifications
R: -111 - -7 (UniProt: P0ABE7)
R: 1 - 224 (UniProt: P61073)
R: 249 - 327 (UniProt: P61073)
| PDB | External Database | Details |
|---|---|---|
| Met -137 | - | initiating methionine |
| Lys -136 | - | expression tag |
| Thr -135 | - | expression tag |
| Ile -134 | - | expression tag |
| Ile -133 | - | expression tag |
| Ala -132 | - | expression tag |
| Leu -131 | - | expression tag |
| Ser -130 | - | expression tag |
| Tyr -129 | - | expression tag |
| Ile -128 | - | expression tag |
| Phe -127 | - | expression tag |
| Cys -126 | - | expression tag |
| Leu -125 | - | expression tag |
| Val -124 | - | expression tag |
| Phe -123 | - | expression tag |
| Ala -122 | - | expression tag |
| Asp -121 | - | expression tag |
| Tyr -120 | - | expression tag |
| Lys -119 | - | expression tag |
| Asp -118 | - | expression tag |
| Asp -117 | - | expression tag |
| Asp -116 | - | expression tag |
| Asp -115 | - | expression tag |
| Lys -114 | - | expression tag |
| Gly -113 | - | expression tag |
| Ser -112 | - | expression tag |
| Trp -105 | Met 29 | conflict |
| Ile -10 | His 124 | conflict |
| Leu -6 | - | linker |
| Leu -5 | - | linker |
| Val -4 | - | linker |
| Pro -3 | - | linker |
| Arg -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp 125 | Leu 125 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 225 | - | linker |
| Leu 226 | - | linker |
| Lys 227 | - | linker |
| Ser 228 | - | linker |
| Val 229 | - | linker |
| Arg 230 | - | linker |
| Leu 231 | - | linker |
| Leu 232 | - | linker |
| Ser 233 | - | linker |
| Gly 234 | - | linker |
| Ser 235 | - | linker |
| Arg 236 | - | linker |
| Glu 237 | - | linker |
| Lys 238 | - | linker |
| Asp 239 | - | linker |
| Arg 240 | - | linker |
| Asn 241 | - | linker |
| Leu 242 | - | linker |
| Arg 243 | - | linker |
| Arg 244 | - | linker |
| Ile 245 | - | linker |
| Thr 246 | - | linker |
| Arg 247 | - | linker |
| Pro 248 | - | linker |
| Gly 328 | - | expression tag |
| Arg 329 | - | expression tag |
| Pro 330 | - | expression tag |
| Leu 331 | - | expression tag |
| Glu 332 | - | expression tag |
| Val 333 | - | expression tag |
| Leu 334 | - | expression tag |
| Phe 335 | - | expression tag |
| Gln 336 | - | expression tag |
| Gly 337 | - | expression tag |
| Pro 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
| His 347 | - | expression tag |
| His 348 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74117.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1122.8 | |
| All* | Total formula weight | 75239.7 |
