8ZP1
Cryo-EM structure of human norepinephrine transporter NET bound with reboxetine in an outward-open state at a resolution of 2.5 angstrom
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent noradrenaline transporter | polymer | 571 | 64298.6 | 1 | UniProt (P23975) Pfam (PF00209) | Homo sapiens (human) | human norepinephrine transporter NET,Norepinephrine transporter,NET,Solute carrier family 6 member 2 |
| 2 | B (B) | Nb_BB4 | polymer | 120 | 13338.7 | 1 | Lama glama | ||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | (2~{S})-2-[(~{S})-(2-ethoxyphenoxy)-phenyl-methyl]morpholine | non-polymer | 313.4 | 1 | Chemie (A1D9Y) | |||
| 5 | E, F (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | G (A) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 1 | Chemie (PTY) | |||
| 7 | H, I (A, B) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77637.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1128.9 | |
| All* | Total formula weight | 78766.2 |
