8ZOU
Respirasome open state 2 in presence of metformin (SC-MetO2)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (4L) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10827.3 | 1 | UniProt (P56632) Pfam (PF00420) | Sus scrofa (pig) | NADH dehydrogenase subunit 4L |
| 2 | B (5A) | Cytochrome c oxidase subunit 5A, mitochondrial | polymer | 102 | 11717.3 | 1 | UniProt (F1SJ34) Pfam (PF02284) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide Va |
| 3 | C (5B) | Cytochrome c oxidase subunit 5B, mitochondrial | polymer | 95 | 10382.7 | 1 | UniProt (Q5S3G4) Pfam (PF01215) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide Vb |
| 4 | D (6A) | Cytochrome c oxidase subunit | polymer | 75 | 8724.9 | 1 | UniProt (A0A287AEB7) Pfam (PF02046) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide VIa |
| 5 | E (6B) | Cytochrome c oxidase subunit | polymer | 82 | 9724.0 | 1 | UniProt (A0A4X1TG97) Pfam (PF02297) | Sus scrofa (pig) | |
| 6 | F (6C) | Cytochrome c oxidase subunit 6C | polymer | 70 | 8139.6 | 1 | UniProt (A0A4X1TXH1) Pfam (PF02937) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide VIc |
| 7 | G (7A) | Cytochrome c oxidase subunit 7A1, mitochondrial | polymer | 57 | 6376.3 | 1 | UniProt (Q8SPJ9) Pfam (PF02238) | Sus scrofa (pig) | Cytochrome c oxidase subunit VIIa-heart,Cytochrome c oxidase subunit VIIa-H |
| 8 | H (7B) | Cytochrome c oxidase subunit 7B, mitochondrial | polymer | 50 | 5543.2 | 1 | UniProt (A0A287BJ57) Pfam (PF05392) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide VIIb |
| 9 | I (7C) | Cytochrome c oxidase subunit 7C, mitochondrial | polymer | 47 | 5465.4 | 1 | UniProt (Q1W0Y2) Pfam (PF02935) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide VIIc |
| 10 | J (8B) | Cytochrome c oxidase subunit 8 | polymer | 43 | 4776.5 | 1 | UniProt (A0A4X1VY94) Pfam (PF02285) UniProt (by SIFTS) (A1XQT4) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide VIII |
| 11 | K (A1) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8034.4 | 1 | UniProt (K7GR43) Pfam (PF15879) | Sus scrofa (pig) | Complex I-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 12 | L (A2) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 85 | 9770.2 | 1 | UniProt (F1RGE3) Pfam (PF05047) | Sus scrofa (pig) | |
| 13 | M (A3) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 83 | 9094.4 | 1 | UniProt (A0A4X1VPG4) Pfam (PF14987) | Sus scrofa (pig) | Complex I-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 14 | N (A5) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 112 | 12949.1 | 1 | UniProt (A0A8D1IJ52) | Sus scrofa (pig) | |
| 15 | O (A6) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 114 | 13755.9 | 1 | UniProt (F1SJP6) Pfam (PF05347) | Sus scrofa (pig) | Complex I-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 16 | P (A7) | Complex I-B14.5a | polymer | 112 | 12517.4 | 1 | UniProt (A0A4X1VLA2) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 17 | Q (A8) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 171 | 19932.9 | 1 | UniProt (F1SLR1) Pfam (PF06747) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 19 kDa subunit,Complex I-19kD |
| 18 | R (A9) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 341 | 38840.9 | 1 | UniProt (F1SL07) Pfam (PF01370) | Sus scrofa (pig) | Complex I-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 19 | S, T (AB, AC) | Acyl carrier protein | polymer | 156 | 17308.2 | 2 | UniProt (A0A287AAR5) Pfam (PF00550) | Sus scrofa (pig) | |
| 20 | U (AK) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 320 | 36792.7 | 1 | UniProt (F1SIS9) Pfam (PF01712) | Sus scrofa (pig) | |
| 21 | V (AL) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 140 | 14555.7 | 1 | UniProt (I3LGM4) Pfam (PF02466) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase subunit B14.7,Complex I-B14.7 |
| 22 | W (AM) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 144 | 17031.2 | 1 | UniProt (F1SQP4) Pfam (PF05071) | Sus scrofa (pig) | |
| 23 | X (AN) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 142 | 16709.3 | 1 | UniProt (A0A8D1NRT6) Pfam (PF06212) | Sus scrofa (pig) | |
| 24 | Y (B1) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 56 | 6781.9 | 1 | UniProt (A0A8D2CGH8) Pfam (PF08040) | Sus scrofa (pig) | Complex I-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 25 | Z (B2) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 67 | 8201.1 | 1 | UniProt (A0A5G2QW32) Pfam (PF14813) | Sus scrofa (pig) | Complex I-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 26 | AA (B3) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 80 | 9042.2 | 1 | UniProt (A0A4X1VD84) Pfam (PF08122) | Sus scrofa (pig) | Complex I-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 27 | BA (B4) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 128 | 14986.2 | 1 | UniProt (A0A4X1T6M0) Pfam (PF07225) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase B15 subunit,Complex I-B15 |
| 28 | CA (B5) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 138 | 16281.9 | 1 | UniProt (F1SGC6) Pfam (PF09781) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase SGDH subunit,Complex I-SGDH |
| 29 | DA (B6) | Complex I-B17 | polymer | 126 | 15333.8 | 1 | UniProt (Q2EN80) UniProt (by SIFTS) (A0A4X1UIV8) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH-ubiquinone oxidoreductase B17 subunit |
| 30 | EA (B7) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 125 | 15307.6 | 1 | UniProt (F1SCH1) Pfam (PF05676) | Sus scrofa (pig) | Complex I-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 31 | FA (B8) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 156 | 18608.8 | 1 | UniProt (F1RWL7) Pfam (PF05821) | Sus scrofa (pig) | Complex I-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 32 | GA (B9) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 178 | 21733.7 | 1 | UniProt (K7GSE5) Pfam (PF05347) | Sus scrofa (pig) | Complex I-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 33 | HA (BK) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 20944.8 | 1 | UniProt (A0A4X1VYV0) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW |
| 34 | IA (BL) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 102 | 12113.5 | 1 | UniProt (A0A8D1EYI7) | Sus scrofa (pig) | Complex I-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 35 | JA (C1) | Cytochrome c oxidase subunit 1 | polymer | 514 | 56992.7 | 1 | UniProt (O79876) Pfam (PF00115) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide I |
| 36 | KA (C2) | Cytochrome c oxidase subunit 2 | polymer | 228 | 26203.6 | 1 | UniProt (P50667) Pfam (PF02790) Pfam (PF00116) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide II |
| 37 | LA (C3) | Cytochrome c oxidase subunit 3 | polymer | 261 | 29753.4 | 1 | UniProt (Q35916) Pfam (PF00510) | Sus scrofa (pig) | Cytochrome c oxidase polypeptide III |
| 38 | MA (C4) | Cytochrome c oxidase subunit 4 | polymer | 138 | 16323.6 | 1 | UniProt (A0A4X1T8J9) | Sus scrofa (pig) | |
| 39 | NA (CA) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 49 | 5881.8 | 1 | UniProt (A1XQS6) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase KFYI subunit,Complex I-KFYI |
| 40 | OA (CB) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 121 | 14196.5 | 1 | UniProt (A0A480JRW3) Pfam (PF06374) | Sus scrofa (pig) | |
| 41 | PA (N1) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35667.5 | 1 | UniProt (O79874) Pfam (PF00146) | Sus scrofa (pig) | NADH dehydrogenase subunit 1 |
| 42 | QA (N2) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39077.5 | 1 | UniProt (O79875) Pfam (PF00361) Pfam (PF06444) | Sus scrofa (pig) | NADH dehydrogenase subunit 2 |
| 43 | RA (N3) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 114 | 12869.3 | 1 | UniProt (O79880) Pfam (PF00507) | Sus scrofa (pig) | NADH dehydrogenase subunit 3 |
| 44 | SA (N4) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51853.4 | 1 | UniProt (Q7IIB7) | Sus scrofa (pig) | |
| 45 | TA (N5) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 603 | 68267.0 | 1 | UniProt (Q71K68) | Sus scrofa (pig) | |
| 46 | UA (N6) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 174 | 18890.1 | 1 | UniProt (O79882) Pfam (PF00499) | Sus scrofa (pig) | NADH dehydrogenase subunit 6 |
| 47 | GB, VA (QA, Qa) | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 419 | 44727.2 | 2 | UniProt (F1RPD2) Pfam (PF00675) Pfam (PF05193) | Sus scrofa (pig) | Ubiquinol-cytochrome c reductase core protein 2 |
| 48 | HB, WA (QB, Qb) | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 446 | 49270.1 | 2 | UniProt (A0A8D0PK14) | Sus scrofa (pig) | |
| 49 | IB, XA (QC, Qc) | Cytochrome b | polymer | 379 | 42840.7 | 2 | UniProt (Q1HBG9) Pfam (PF00033) Pfam (PF00032) | Sus scrofa (pig) | |
| 50 | JB, YA (QD, Qd) | Cytochrome c domain-containing protein | polymer | 241 | 27373.4 | 2 | UniProt (A0A8D0K1H3) | Sus scrofa (pig) | |
| 51 | FB, KB, ZA (QE, QK, Qe) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 274 | 29492.6 | 3 | UniProt (A0A4X1TWD8) | Sus scrofa (pig) | |
| 52 | AB, LB (QF, Qf) | Cytochrome b-c1 complex subunit 6 | polymer | 67 | 7933.9 | 2 | UniProt (F1S3W0) Pfam (PF02320) | Sus scrofa (pig) | |
| 53 | BB, MB (QG, Qg) | Cytochrome b-c1 complex subunit 7 | polymer | 101 | 12644.4 | 2 | UniProt (A0A4X1U2M7) | Sus scrofa (pig) | |
| 54 | CB, NB (QH, Qh) | Cytochrome b-c1 complex subunit 8 | polymer | 81 | 9653.1 | 2 | UniProt (A0A4X1UYT9) Pfam (PF02939) | Sus scrofa (pig) | Complex III subunit 8 |
| 55 | DB, OB (QI, Qi) | Complex III subunit 9 | polymer | 63 | 7281.3 | 2 | UniProt (Q2EN79) Pfam (PF05365) | Sus scrofa (pig) | |
| 56 | EB, PB (QJ, Qj) | Cytochrome b-c1 complex subunit 10 | polymer | 52 | 6058.1 | 2 | UniProt (A0A4X1VTU3) | Sus scrofa (pig) | |
| 57 | QB (S1) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 689 | 75683.7 | 1 | UniProt (A0A8D1F3I4) | Sus scrofa (pig) | |
| 58 | RB (S2) | Complex I-49kD | polymer | 430 | 49234.3 | 1 | UniProt (A0A480JYS1) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2,mitochondrial,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 59 | SB (S3) | Complex I-30kD | polymer | 208 | 24521.7 | 1 | UniProt (A0A286ZNN4) Pfam (PF00329) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3,mitochondrial,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 60 | TB (S4) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 124 | 14314.3 | 1 | UniProt (A0A4X1SN37) Pfam (PF04800) | Sus scrofa (pig) | Complex I-18 kDa,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 61 | UB (S5) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 105 | 12375.4 | 1 | UniProt (F1SV23) Pfam (PF10200) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 15 kDa subunit,Complex I-15 kDa |
| 62 | VB (S6) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 96 | 10567.6 | 1 | UniProt (F1S031) Pfam (PF10276) | Sus scrofa (pig) | |
| 63 | WB (S7) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 156 | 17875.0 | 1 | UniProt (A0A8D1J578) | Sus scrofa (pig) | Complex I-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 64 | XB (S8) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 176 | 20208.0 | 1 | UniProt (A0A287BDC0) Pfam (PF12838) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 23 kDa subunit,Complex I-23kD |
| 65 | YB (V1) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 431 | 47235.8 | 1 | UniProt (A0A4X1SZP7) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Sus scrofa (pig) | |
| 66 | ZB (V2) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 217 | 23826.3 | 1 | UniProt (A0A287BG40) Pfam (PF01257) | Sus scrofa (pig) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 67 | AC (V3) | Complex I-9kD | polymer | 42 | 5046.5 | 1 | UniProt (A0A4X1TFI3) | Sus scrofa (pig) | NADH dehydrogenase [ubiquinone] flavoprotein 3,mitochondrial,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 68 | AG, BC, BD, BF, CF... (Qc, 4L, AN, QC, B4...) | CARDIOLIPIN | non-polymer | 1464.0 | 24 | Chemie (CDL) | |||
| 69 | CC, OG (5B, S6) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 70 | AE, BE, BG, DC, DG... (C3, C4, Qc, 6A, Qd...) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 29 | Chemie (PC1) | |||
| 71 | AD, AF, EC, FC, FE... (AN, QC, 6A, CB, Qe...) | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine | non-polymer | 744.0 | 27 | Chemie (PEE) | |||
| 72 | CE, EE, HC, KD, QF... (CA, CB, 7B, C1, Qc) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 6 | Chemie (3PE) | |||
| 73 | OC (A9) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 74 | PC, QC (AB, AC) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 2 | Chemie (ZMP) PubChem (24941266) | |||
| 75 | RC (AK) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 76 | CD, DE, FF, IE, JD... (B1, CB, QE, N3, BL...) | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL | non-polymer | 767.1 | 10 | Chemie (PLX) | |||
| 77 | LD, MD (C1) | HEME-A | non-polymer | 852.8 | 2 | Chemie (HEA) | |||
| 78 | ND, VD, WD (C1, C2) | COPPER (II) ION | non-polymer | 63.5 | 3 | Chemie (CU) PubChem (27099) | |||
| 79 | NG, OD (S1, C1) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 80 | TF, UF, WE, XE (Qc, QC) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 81 | CG, DF (Qd, QD) | HEME C | non-polymer | 618.5 | 2 | Chemie (HEC) | |||
| 82 | EG, HF, MG, XG (Qe, QE, S1, V2) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 4 | Chemie (FES) | |||
| 83 | IF (QH) | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE | non-polymer | 535.7 | 1 | Chemie (PX2) | |||
| 84 | KG, LG, PG, RG, SG... (S1, S7, S8, V1) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 85 | WG (V1) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (643976) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 79 |
| Total formula weight | 1666520.6 | |
| Non-Polymers* | Number of molecules | 127 |
| Total formula weight | 102193.7 | |
| All* | Total formula weight | 1768714.3 |
