8ZNL
PD-L1 de novo designed binder with picomolar binding affinity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | PD-L1 de novo binder | polymer | 58 | 6988.1 | 4 | Escherichia coli | ||
| 2 | B, D, F, H (B, D, F, H) | Programmed cell death 1 ligand 1 | polymer | 114 | 13121.1 | 4 | UniProt (Q9NZQ7) Pfam (PF07686) | Homo sapiens (human) | PD-L1,PDCD1 ligand 1,Programmed death ligand 1,hPD-L1,B7 homolog 1,B7-H1 |
| 3 | I, J, K, L (A, D, E, H) | BROMIDE ION | non-polymer | 79.9 | 4 | Chemie (BR) PubChem (259) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 395 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 20 - 133 (UniProt: Q9NZQ7)
| PDB | External Database | Details |
|---|---|---|
| Lys 133 | Ala 132 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 80436.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 319.6 | |
| All* | Total formula weight | 80756.4 |
