8ZJG
Cryo-EM structure of human CMKLR1-Gi complex bound to chemerin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chemerin-like receptor 1 | polymer | 373 | 42362.8 | 1 | UniProt (Q99788) Pfam (PF00001) | Homo sapiens (human) | Chemokine-like receptor 1,G-protein coupled receptor ChemR23,G-protein coupled receptor DEZ |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 351 | 40153.7 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (S) | scFV16 | polymer | 247 | 26337.3 | 1 | Vicugna pacos | ||
| 6 | F (L) | Retinoic acid receptor responder protein 2 chemerinv | polymer | 137 | 15904.2 | 1 | UniProt (Q99969) | Homo sapiens (human) | Chemerin |
| 7 | G, H, I, J (A) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 8 | K (L) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
C: 4 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 170036.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1546.6 | |
| All* | Total formula weight | 171582.7 |
