8ZGS
Structure of the ige-fc bound to its high affinity receptor fc(epsilon)ri state2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | High affinity immunoglobulin epsilon receptor subunit alpha | polymer | 245 | 27830.2 | 1 | UniProt (P12371) Pfam (PF13895) In PDB | Rattus norvegicus (Norway rat) | Fc-epsilon RI-alpha,FcERI,IgE Fc receptor subunit alpha |
| 2 | B | High affinity immunoglobulin epsilon receptor subunit beta | polymer | 243 | 26747.8 | 1 | UniProt (P13386) Pfam (PF04103) In PDB | Rattus norvegicus (Norway rat) | FcERI,Fc epsilon receptor I beta-chain,IgE Fc receptor subunit beta |
| 3 | C, G | High affinity immunoglobulin epsilon receptor subunit gamma | polymer | 86 | 9774.5 | 2 | UniProt (P20411) Pfam (PF11628) Pfam (PF02189) In PDB | Rattus norvegicus (Norway rat) | Fc receptor gamma-chain,FcRgamma,Fc-epsilon RI-gamma,IgE Fc receptor subunit gamma,FceRI gamma |
| 4 | E, F | Immunoglobulin heavy constant epsilon | polymer | 374 | 43155.8 | 2 | UniProt (P01855) Pfam (PF07654) Pfam (PF00047) In PDB | Rattus norvegicus (Norway rat) | Ig epsilon chain C region |
| 5 | T | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | D, H | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 7 | A, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 8 | B | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) |
Sequence modifications
E, F: 95 - 429 (UniProt: P01855)
| PDB | External Database | Details |
|---|---|---|
| Met 73 | - | initiating methionine |
| Ser 74 | - | expression tag |
| Val 75 | - | expression tag |
| Pro 76 | - | expression tag |
| Thr 77 | - | expression tag |
| Gln 78 | - | expression tag |
| Val 79 | - | expression tag |
| Leu 80 | - | expression tag |
| Gly 81 | - | expression tag |
| Leu 82 | - | expression tag |
| Leu 83 | - | expression tag |
| Leu 84 | - | expression tag |
| Leu 85 | - | expression tag |
| Trp 86 | - | expression tag |
| Leu 87 | - | expression tag |
| Thr 88 | - | expression tag |
| Asp 89 | - | expression tag |
| Ala 90 | - | expression tag |
| Arg 91 | - | expression tag |
| Cys 92 | - | expression tag |
| Asp 93 | - | expression tag |
| Ile 94 | - | expression tag |
| His 430 | - | expression tag |
| His 431 | - | expression tag |
| His 432 | - | expression tag |
| His 433 | - | expression tag |
| His 434 | - | expression tag |
| His 435 | - | expression tag |
| Ser 436 | - | expression tag |
| Arg 437 | - | expression tag |
| Val 438 | - | expression tag |
| Asp 439 | - | expression tag |
| Tyr 440 | - | expression tag |
| Lys 441 | - | expression tag |
| Asp 442 | - | expression tag |
| Asp 443 | - | expression tag |
| Asp 444 | - | expression tag |
| Asp 445 | - | expression tag |
| Lys 446 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 160438.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1597.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1592.8 | |
| All* | Total formula weight | 163628.8 |
