8ZBJ
Cryo-EM structure of Somatostatin receptor 5 (SSTR5) with Gi1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (S) | Somatostatin-14 | polymer | 14 | 1641.9 | 1 | UniProt (P61278) Pfam (PF03002) BIRD (PRD_001216) | Homo sapiens (human) | SST14 |
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (E) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (F) | scFv16 | polymer | 296 | 31617.4 | 1 | Homo sapiens (human) | ||
| 5 | E (R) | Soluble cytochrome b562,Somatostatin receptor type 5 | polymer | 470 | 51002.3 | 1 | UniProt (P0ABE7) UniProt (P35346) Pfam (PF00001) | Homo sapiens (human) | Cytochrome b-562,SS-5-R,SS5-R,SS5R,SST5 |
| 6 | F (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
Sequence modifications
C: 2 - 340 (UniProt: P62873)
R: -105 - -1 (UniProt: P0ABE7)
R: 1 - 364 (UniProt: P35346)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp -99 | Met 29 | conflict |
| Ile -4 | His 124 | conflict |
| Leu 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 170265.9 | |
| All* | Total formula weight | 170265.9 |
