8ZA6

Cryo-EM structure of the gdTCR-CD3 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (a, b)	T-cell surface glycoprotein CD3 zeta chain	polymer	165	18810.5	2	UniProt (P20963) Pfam (PF11628) Pfam (PF02189)	Homo sapiens (human)	T-cell receptor T3 zeta chain
2	C (d)	T-cell surface glycoprotein CD3 delta chain	polymer	171	18949.5	1	UniProt (P04234) Pfam (PF16680) Pfam (PF02189)	Homo sapiens (human)	T-cell receptor T3 delta chain
3	D, E (e, f)	T-cell surface glycoprotein CD3 epsilon chain	polymer	207	23174.2	2	UniProt (P07766) Pfam (PF16681) Pfam (PF02189)	Homo sapiens (human)	T-cell surface antigen T3/Leu-4 epsilon chain
4	F (g)	T-cell surface glycoprotein CD3 gamma chain	polymer	182	20493.5	1	UniProt (P09693) Pfam (PF16680) Pfam (PF02189)	Homo sapiens (human)	T-cell receptor T3 gamma chain
5	G (m)	TRA@ protein	polymer	290	32389.4	1	UniProt (Q6PJ56) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (human)
6	H (n)	CD3	polymer	328	37324.6	1		Homo sapiens (human)
7	I (b)	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)

Sequence modifications

a, b: 1 - 164 (UniProt: P20963)

PDB	External Database	Details
Ser 165	-	expression tag

m: 1 - 114 (UniProt: Q6PJ56)
m: 121 - 290 (UniProt: Q6PJ56)

PDB	External Database	Details
Asp 115	-	linker
Pro 116	-	linker
Gly 117	-	linker
Gly 118	-	linker
Leu 119	-	linker
Asn 120	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	193126.5
Non-Polymers*	Number of molecules	1
	Total formula weight	386.7
All*	Total formula weight	193513.2

*Water molecules are not included.