8Z6S

Structure of XBB.1.16 S trimer with 2 down-RBDs complex with antibody CYFN1006-1.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (D, F, H)	CYFN1006-1 light chain	polymer	215	22730.2	3		Homo sapiens (human)
2	B, D, F (E, G, I)	CYFN1006-1 heavy chain	polymer	451	49553.9	3		Homo sapiens (human)
3	G, H, I (C, B, A)	Spike glycoprotein,Fibritin,Expression Tag	polymer	1299	143630.2	3	UniProt (P0DTC2) UniProt (P10104) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2	S glycoprotein,E2,Peplomer protein,Collar protein,Whisker antigen control protein

Sequence modifications

C, B, A: 18 - 1212 (UniProt: P0DTC2)

PDB	External Database	Details
Met -6	-	initiating methionine
Pro -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Gln 0	-	expression tag
Pro 1	-	expression tag
Leu 2	-	expression tag
Ala 3	-	expression tag
Thr 4	-	expression tag
Leu 5	-	expression tag
Tyr 6	-	expression tag
Leu 7	-	expression tag
Leu 8	-	expression tag
Gly 9	-	expression tag
Met 10	-	expression tag
Leu 11	-	expression tag
Val 12	-	expression tag
Ala 13	-	expression tag
Ser 14	-	expression tag
Val 15	-	expression tag
Leu 16	-	expression tag
Ala 17	-	expression tag
Ile 23	Thr 19	variant
-	Leu 24	deletion
-	Pro 25	deletion
-	Pro 26	deletion
Ser 28	Ala 27	variant
Ala 84	Val 83	variant
Asp 143	Gly 142	variant
-	Tyr 144	deletion
Gln 146	His 146	variant
Val 180	Glu 180	conflict
Glu 183	Gln 183	variant
Glu 213	Val 213	variant
Val 252	Gly 252	variant
His 339	Gly 339	variant
Thr 346	Arg 346	variant
Ile 368	Leu 368	variant
Phe 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ala 376	Thr 376	variant
Asn 405	Asp 405	variant
Ser 408	Arg 408	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Pro 445	Val 445	variant
Ser 446	Gly 446	variant
Lys 460	Asn 460	variant
Asn 477	Ser 477	variant
Arg 478	Thr 478	conflict
Ala 484	Glu 484	variant
Pro 486	Phe 486	variant
Ser 490	Phe 490	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant
Gly 614	Asp 614	variant
Tyr 655	His 655	variant
Lys 679	Asn 679	variant
His 681	Pro 681	variant
Gly 682	Arg 682	conflict
Ser 683	Arg 683	conflict
Ser 685	-	insertion
Ser 686	-	insertion
Lys 687	-	insertion
Ser 689	-	insertion
Lys 768	Asn 764	variant
Tyr 800	Asp 796	variant
Pro 821	Phe 817	conflict
Pro 896	Ala 892	conflict
Pro 903	Ala 899	conflict
Pro 946	Ala 942	conflict
His 958	Gln 954	variant
Lys 973	Asn 969	variant
Pro 990	Lys 986	variant
Pro 991	Val 987	variant
Gly 1213	-	linker
Ser 1214	-	linker

C, B, A: 1215 - 1242 (UniProt: P10104)
C, B, A: 1243 - 1292 (PDB: 8Z6S)

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	647742.8
All*	Total formula weight	647742.8

*Water molecules are not included.