8Z4W
Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Non-structural protein 3 | polymer | 316 | 35802.7 | 4 | UniProt (P0DTC1) Pfam (PF08715) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | nsp3, PL2-PRO, Papain-like protease, Papain-like proteinase, PL-PRO |
| 2 | E, G, I, M (A, B, C, D) | 1-[4-[[[4-(isoquinolin-5-ylamino)-6-(methylamino)-1,3,5-triazin-2-yl]amino]methyl]piperidin-1-yl]ethanone | non-polymer | 406.5 | 4 | Chemie (A1D7X) | |||
| 3 | F, H, L, N (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | J, K (C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | O, P, Q (B, C, D) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 315 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 143210.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2071.8 | |
| All* | Total formula weight | 145282.5 |
