8Z33

Crystal Structure of HIF-PHD2 in complex with compound 4

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Egl nine homolog 1	polymer	247	27832.7	2	UniProt (Q9GZT9) Pfam (PF13640)	Homo sapiens (human)	Hypoxia-inducible factor prolyl hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20
2	C, F (A, B)	FE (II) ION	non-polymer		55.8	2	Chemie (FE2)
3	D, G (A, B)	FLUORIDE ION	non-polymer		19.0	2	Chemie (F)
4	E, H (A, B)	2-[[6-[2-(4-fluorophenyl)ethyl]-2-methyl-5-oxidanyl-pyrimidin-4-yl]carbonylamino]ethanoic acid	non-polymer		333.3	2	Chemie (A1L0W)
5	I, J (A, B)	water	water		18.0	37	Chemie (HOH)

Sequence modifications

A, B: 188 - 426 (UniProt: Q9GZT9)

PDB	External Database	Details
Met 180	-	initiating methionine
Ala 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55665.3
Non-Polymers*	Number of molecules	6
	Total formula weight	816.3
All*	Total formula weight	56481.7

*Water molecules are not included.