8Z1S
Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Galectin-3 | polymer | 179 | 19348.0 | 2 | UniProt (P17931) Pfam (PF00337) | Homo sapiens (human) | Gal-3,35 kDa lectin,Carbohydrate-binding protein 35,CBP 35,Galactose-specific lectin 3,Galactoside-binding protein,GALBP,IgE-binding protein,L-31,Laminin-binding protein,Lectin L-29,Mac-2 antigen |
| 2 | C, E (A, B) | (2~{S},3~{R},4~{R},5~{R},6~{R})-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-2-[4-[5-chloranyl-2-(trifluoromethyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-6-(hydroxymethyl)oxane-3,5-diol | non-polymer | 621.3 | 2 | Chemie (A1L0Q) | |||
| 3 | D (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 265 | Chemie (HOH) |
Sequence modifications
A, B: 72 - 250 (UniProt: P17931)
| PDB | External Database | Details |
|---|---|---|
| His 106 | Pro 106 | engineered mutation |
| Met 107 | Tyr 107 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38696.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1278.1 | |
| All* | Total formula weight | 39974.1 |
