8YZC

Structure of BA.2.86 spike protein in complex with ACE2.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Spike glycoprotein,Fibritin,Expression Tag	polymer	1291	142889.4	3	UniProt (P0DTC2) UniProt (P10104) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	S glycoprotein,E2,Peplomer protein,Collar protein,Whisker antigen control protein
2	D, E, F (G, H, I)	Angiotensin-converting enzyme 2	polymer	742	85831.8	3	UniProt (Q9BYF1) Pfam (PF01401) Pfam (PF16959)	Homo sapiens (human)	Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15

Sequence modifications

A, B, C: 21 - 1208 (UniProt: P0DTC2)

PDB	External Database	Details
Met -3	-	initiating methionine
Pro -2	-	expression tag
Met -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Leu 2	-	expression tag
Gln 3	-	expression tag
Pro 4	-	expression tag
Leu 5	-	expression tag
Ala 6	-	expression tag
Thr 7	-	expression tag
Leu 8	-	expression tag
Tyr 9	-	expression tag
Leu 10	-	expression tag
Leu 11	-	expression tag
Gly 12	-	expression tag
Met 13	-	expression tag
Leu 14	-	expression tag
Val 15	-	expression tag
Ala 16	-	expression tag
Ser 17	-	expression tag
Val 18	-	expression tag
Leu 19	-	expression tag
Ala 20	-	expression tag
Ile 26	Thr 19	variant
Thr 28	Arg 21	conflict
-	Leu 24	deletion
-	Pro 25	deletion
-	Pro 26	deletion
Ser 31	Ala 27	variant
Leu 54	Ser 50	conflict
-	His 69	deletion
-	Val 70	deletion
Phe 128	Val 126	conflict
Asp 144	Gly 142	variant
-	Tyr 144	deletion
Ser 158	Phe 157	conflict
Gly 159	Arg 158	conflict
-	Asn 211	deletion
Ile 212	Leu 212	conflict
Gly 213	Val 213	variant
Phe 216	Leu 216	variant
Asn 245	His 245	variant
Asp 264	Ala 264	variant
Val 332	Ile 332	variant
His 339	Gly 339	variant
Thr 356	Lys 356	variant
Phe 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ala 376	Thr 376	variant
Lys 403	Arg 403	variant
Asn 405	Asp 405	variant
Ser 408	Arg 408	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
His 445	Val 445	variant
Ser 446	Gly 446	variant
Asp 450	Asn 450	variant
Trp 452	Leu 452	variant
Lys 460	Asn 460	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	conflict
Lys 481	Asn 481	conflict
-	Val 483	deletion
Lys 484	Glu 484	variant
Pro 486	Phe 486	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	conflict
Lys 554	Glu 554	conflict
Val 570	Ala 570	conflict
Gly 614	Asp 614	variant
Ser 621	Pro 621	conflict
Tyr 655	His 655	variant
Val 670	Ile 670	conflict
Lys 679	Asn 679	variant
Arg 681	Pro 681	variant
Gly 682	Arg 682	conflict
Ser 683	Arg 683	conflict
Ser 685	Arg 685	conflict
Lys 764	Asn 764	variant
Tyr 796	Asp 796	variant
Pro 817	Phe 817	conflict
Pro 892	Ala 892	conflict
Pro 899	Ala 899	conflict
Phe 939	Ser 939	conflict
Pro 942	Ala 942	conflict
His 954	Gln 954	variant
Lys 969	Asn 969	variant
Pro 986	Lys 986	variant
Pro 987	Val 987	variant
Leu 1143	Pro 1143	conflict
Gly 1209	-	linker
Ser 1210	-	linker

A, B, C: 1211 - 1234 (UniProt: P10104)
A, B, C: 1235 - 1288 (PDB: 8YZC)
G, H, I: 1 - 732 (UniProt: Q9BYF1)

PDB	External Database	Details
Ser 733	-	expression tag
Gly 734	-	expression tag
His 735	-	expression tag
His 736	-	expression tag
His 737	-	expression tag
His 738	-	expression tag
His 739	-	expression tag
His 740	-	expression tag
His 741	-	expression tag
His 742	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	686163.5
All*	Total formula weight	686163.5

*Water molecules are not included.