8YTE

Crystal Structure of TrkA D5 domain in complex with macrocyclic peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	High affinity nerve growth factor receptor	polymer	102	11221.6	2	UniProt (P04629) In PDB	Homo sapiens (human)	Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
2	B, D	Macrocyclic Peptide	polymer	14	1620.9	2		synthetic construct
3	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	9	Chemie (EDO)
4	B, D	AMINOMETHYLAMIDE	non-polymer		74.1	2	Chemie (GM1)
5		water	water		18.0	91	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	25684.9
Non-Polymers*	Number of molecules	11
	Total formula weight	706.8
All*	Total formula weight	26391.7

*Water molecules are not included.