8YS4

Overall structure of Eastern Equine Encephalitis virus VLP in complex with the receptor VLDLR LA3-5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (A, D, G, J)	Spike glycoprotein E1	polymer	441	47984.2	4	UniProt (Q4QXJ7)	Eastern equine encephalitis virus	E1 envelope glycoprotein
2	B, E, H, K (B, E, H, K)	Spike glycoprotein E2	polymer	420	47047.0	4	UniProt (Q4QXJ7)	Eastern equine encephalitis virus	E2 envelope glycoprotein
3	C, F, I, L (C, F, I, L)	Capsid protein	polymer	261	29178.8	4	UniProt (Q4QXJ7)	Eastern equine encephalitis virus	Coat protein,C
4	M, N, O, P (M, N, O, P)	Very low-density lipoprotein receptor	polymer	41	4428.7	4	UniProt (P98155) Pfam (PF00057)	Homo sapiens (human)	VLDL receptor,VLDL-R
5	Q, R, S, T (Q, R, S, T)	Very low-density lipoprotein receptor	polymer	41	4532.8	4	UniProt (P98155) Pfam (PF00057)	Homo sapiens (human)	VLDL receptor,VLDL-R
6	AA, BA, U, V, W... (S, T, M, N, O...)	CALCIUM ION	non-polymer		40.1	8	Chemie (CA) PubChem (271)

Sequence modifications

A, D, G, J: 1 - 441 (UniProt: Q4QXJ7)

PDB	External Database	Details
Ser 82	Thr 883	conflict
Val 237	Ala 1038	conflict
Lys 246	Arg 1047	conflict
Phe 311	Ser 1112	conflict
Ile 411	Leu 1212	conflict

B, E, H, K: 1 - 420 (UniProt: Q4QXJ7)

PDB	External Database	Details
Lys 206	Glu 530	conflict

C, F, I, L: 1 - 261 (UniProt: Q4QXJ7)

PDB	External Database	Details
Ser 50	Asn 50	conflict
Asn 67	Lys 67	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	532686.6
Non-Polymers*	Number of molecules	8
	Total formula weight	320.6
All*	Total formula weight	533007.2

*Water molecules are not included.