8YP8

Structure of the p38alpha-pepHePTPm(16-31)(V31C ) complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 14	polymer	379	43378.3	1	UniProt (P47811) Pfam (PF00069)	Mus musculus (house mouse)	MAP kinase 14,MAPK 14,CRK1,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha
2	B (B)	Tyrosine-protein phosphatase non-receptor type 7	polymer	16	1864.2	1	UniProt (P35236)	Homo sapiens	KIM peptide derived from HePTP,Hematopoietic protein-tyrosine phosphatase,HEPTP,Protein-tyrosine phosphatase LC-PTP
3	C, D (A, B)	water	water		18.0	221	Chemie (HOH)

Sequence modifications

A: 1 - 360 (UniProt: P47811)

PDB	External Database	Details
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

B: 16 - 31 (UniProt: P35236)

PDB	External Database	Details
Cys 31	Val 52	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	45242.5
All*	Total formula weight	45242.5

*Water molecules are not included.