8YNN
Structure of the Caspase-8/cFLIP death effector domain assembly
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Caspase-8 subunit p10 | polymer | 479 | 55191.6 | 3 | UniProt (Q14790) Pfam (PF01335) Pfam (PF00656) | Homo sapiens (human) | |
| 2 | D, E, F, G (H, I, J, K) | CASP8 and FADD-like apoptosis regulator subunit p43 | polymer | 181 | 20878.5 | 4 | UniProt (O15519) Pfam (PF01335) | Homo sapiens (human) |
Sequence modifications
A, B, C: 1 - 479 (UniProt: Q14790)
| PDB | External Database | Details |
|---|---|---|
| Gly 122 | Phe 122 | engineered mutation |
| Gly 123 | Leu 123 | engineered mutation |
| Ala 360 | Cys 360 | engineered mutation |
| Ala 374 | Asp 374 | engineered mutation |
| Ala 384 | Asp 384 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 249088.9 | |
| All* | Total formula weight | 249088.9 |
