8YN7
Cryo-EM structure of histamine H3 receptor in complex with immethridine and miniGo
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Engineered guanine nucleotide-binding protein G(o) subunit alpha,Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 226 | 25286.9 | 1 | UniProt (P09471) Pfam (PF00503) | synthetic construct | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 376 | 40845.6 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | Antibody fragment scFv16 | polymer | 255 | 27314.4 | 1 | synthetic construct | ||
| 5 | E (R) | Histamine H3 receptor | polymer | 659 | 72568.7 | 1 | UniProt (Q9Y5N1) Pfam (PF00001) | Homo sapiens (human) | |
| 6 | F (R) | 4-(1H-imidazol-4-ylmethyl)pyridine | non-polymer | 159.2 | 1 | Chemie (A1LY2) | |||
| 7 | G, H, I, J, K (R) | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (18640088) PubChem (1715243) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (1715244) PubChem (23423981) PubChem (45044259) PubChem (638019) PubChem (49853509) PubChem (50990013) PubChem (44654663) PubChem (52934537) PubChem (56621683) PubChem (1549081) PubChem (1553803) PubChem (46937002) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (59274407) PubChem (5283629) PubChem (5284644) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (5315842) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (6419195) PubChem (5997) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (1551269) PubChem (90070115) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (117965027) PubChem (6432564) PubChem (101624109) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (138967089) PubChem (139566851) PubChem (130459183) PubChem (131992107) PubChem (15939944) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (171828367) PubChem (173516975) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) |
Sequence modifications
A: 3 - 181 (PDB: 8YN7)
A: 182 - 354 (UniProt: P09471)
B: 2 - 340 (UniProt: P62873)
R: 1 - 445 (UniProt: Q9Y5N1)
R: 446 - 606 (PDB: 8YN7)
A: 182 - 354 (UniProt: P09471)
| PDB | External Database | Details |
|---|---|---|
| Asp 227 | Ala 227 | engineered mutation |
| Asp 230 | Gly 230 | engineered mutation |
| - | Asp 232 | deletion |
| - | Gln 233 | deletion |
| - | Val 234 | deletion |
| - | Leu 235 | deletion |
| - | His 236 | deletion |
| - | Glu 237 | deletion |
| - | Asp 238 | deletion |
| - | Glu 239 | deletion |
| - | Thr 240 | deletion |
| - | Thr 241 | deletion |
| Ala 332 | Ile 332 | engineered mutation |
| Ile 335 | Val 335 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -52 | - | expression tag |
| Tyr -51 | - | expression tag |
| Lys -50 | - | expression tag |
| Asp -49 | - | expression tag |
| Asp -48 | - | expression tag |
| Asp -47 | - | expression tag |
| Asp -46 | - | expression tag |
| His -45 | - | expression tag |
| His -44 | - | expression tag |
| His -43 | - | expression tag |
| His -42 | - | expression tag |
| His -41 | - | expression tag |
| His -40 | - | expression tag |
| His -39 | - | expression tag |
| His -38 | - | expression tag |
| Gly -37 | - | expression tag |
| Gln -36 | - | expression tag |
| Pro -35 | - | expression tag |
| Gly -34 | - | expression tag |
| Asn -33 | - | expression tag |
| Gly -32 | - | expression tag |
| Ser -31 | - | expression tag |
| Ala -30 | - | expression tag |
| Phe -29 | - | expression tag |
| Leu -28 | - | expression tag |
| Leu -27 | - | expression tag |
| Ala -26 | - | expression tag |
| Pro -25 | - | expression tag |
| Asn -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Ser -22 | - | expression tag |
| His -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Pro -19 | - | expression tag |
| Asp -18 | - | expression tag |
| His -17 | - | expression tag |
| Asn -16 | - | expression tag |
| Val -15 | - | expression tag |
| Thr -14 | - | expression tag |
| Gln -13 | - | expression tag |
| Gln -12 | - | expression tag |
| Arg -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Val -1 | - | expression tag |
| Asp 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 173876.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2092.5 | |
| All* | Total formula weight | 175969.2 |
