8YN5
Cryo-EM structure of histamine H3 receptor in complex with histamine and Gi
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 376 | 40845.6 | 1 | UniProt (P62873) In PDB | Homo sapiens (human) | |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) In PDB | Homo sapiens (human) | G gamma-I |
4 | E | Antibody fragment scFv16 | polymer | 255 | 27314.4 | 1 | synthetic construct | ||
5 | R | Histamine H3 receptor | polymer | 659 | 72568.7 | 1 | UniProt (Q9Y5N1) In PDB | Homo sapiens (human) | H3R,HH3R,G-protein coupled receptor 97 |
6 | R | HISTAMINE | non-polymer | 111.1 | 1 | Chemie (HSM) | |||
7 | R | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
R: 1 - 445 (UniProt: Q9Y5N1)
R: 446 - 606 (PDB: 8YN5)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -52 | - | expression tag |
Tyr -51 | - | expression tag |
Lys -50 | - | expression tag |
Asp -49 | - | expression tag |
Asp -48 | - | expression tag |
Asp -47 | - | expression tag |
Asp -46 | - | expression tag |
His -45 | - | expression tag |
His -44 | - | expression tag |
His -43 | - | expression tag |
His -42 | - | expression tag |
His -41 | - | expression tag |
His -40 | - | expression tag |
His -39 | - | expression tag |
His -38 | - | expression tag |
Gly -37 | - | expression tag |
Gln -36 | - | expression tag |
Pro -35 | - | expression tag |
Gly -34 | - | expression tag |
Asn -33 | - | expression tag |
Gly -32 | - | expression tag |
Ser -31 | - | expression tag |
Ala -30 | - | expression tag |
Phe -29 | - | expression tag |
Leu -28 | - | expression tag |
Leu -27 | - | expression tag |
Ala -26 | - | expression tag |
Pro -25 | - | expression tag |
Asn -24 | - | expression tag |
Gly -23 | - | expression tag |
Ser -22 | - | expression tag |
His -21 | - | expression tag |
Ala -20 | - | expression tag |
Pro -19 | - | expression tag |
Asp -18 | - | expression tag |
His -17 | - | expression tag |
Asn -16 | - | expression tag |
Val -15 | - | expression tag |
Thr -14 | - | expression tag |
Gln -13 | - | expression tag |
Gln -12 | - | expression tag |
Arg -11 | - | expression tag |
Asp -10 | - | expression tag |
Glu -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Gly -2 | - | expression tag |
Val -1 | - | expression tag |
Asp 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 189003.9 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2044.4 | |
All* | Total formula weight | 191048.3 |