8YMB

The crystal structure of SHD931 in complex with Brd4-BD2 and VCB

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, F)	Bromodomain-containing protein 4	polymer	128	14842.1	2	UniProt (O60885) Pfam (PF00439)	Homo sapiens (human)	Protein HUNK1
2	B, F (B, G)	Elongin-B	polymer	122	13436.0	2	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
3	C, G (C, H)	Elongin-C	polymer	98	10987.5	2	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
4	D, H (D, I)	von Hippel-Lindau disease tumor suppressor	polymer	161	18571.1	2	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
5	I, J, K, L, M... (A, B, D, G, H...)	CHLORIDE ION	non-polymer		35.5	8	Chemie (CL)
6	N, R (D, I)	SHD931	non-polymer		990.3	2	Chemie (A1LY0)
7	S, T, U, V, W... (B, C, D, F, G...)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

B, G: 1 - 118 (UniProt: Q15370)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

C, H: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Gly 15	-	expression tag
Ser 16	-	expression tag

D, I: 55 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 53	-	expression tag
Ser 54	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	115673.5
Non-Polymers*	Number of molecules	10
	Total formula weight	2264.2
All*	Total formula weight	117937.7

*Water molecules are not included.