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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8YKD

Cryo-EM structure of ADGRG2-Gs complex with NTF nanobody

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(s) subunit alphapolymer36141879.51UniProt (P63091)
Pfam (PF00503)		Spodoptera
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35839418.11UniProt (P62871)
Pfam (PF25391)		SpodopteraTransducin beta chain 1
3C
(G)		Guanine nucleotide-binding protein subunit gammapolymer10812104.91UniProt (A0A7J7XNR4)Spodoptera
4D
(N)		Nanobody-35polymer12813885.41Spodoptera
5E
(R)		Adhesion G-protein coupled receptor G2polymer90398934.81UniProt (Q8CJ12)
Pfam (PF26152)
Pfam (PF26574)
Pfam (PF01825)
Pfam (PF00002)		SpodopteraG-protein coupled receptor 64,Mouse epididymis-specific protein 6,Me6
6F
(S)		ScFv-16polymer25026640.61Spodoptera
7G
(R)		3-BETA-HYDROXY-5-ANDROSTEN-17-ONEnon-polymer288.41Chemie (AND)
PubChem (16401868)
PubChem (16759247)
PubChem (76)
PubChem (5881)
PubChem (23968375)
PubChem (40467152)
PubChem (40467153)
PubChem (44135505)
PubChem (52231287)
PubChem (1780097)
PubChem (56729336)
PubChem (1780096)
PubChem (57256396)
PubChem (57284772)
PubChem (59742782)
PubChem (59746156)
PubChem (67990409)
PubChem (68237944)
PubChem (70954143)
PubChem (71773373)
PubChem (56828038)
PubChem (2817714)
PubChem (134506)
PubChem (719264)
PubChem (908452)
PubChem (5318142)
PubChem (6432532)
PubChem (10541387)
PubChem (6603817)
PubChem (7048561)
PubChem (117072372)
PubChem (117808186)
PubChem (117809719)
PubChem (117852738)
PubChem (7092995)
PubChem (7200985)
PubChem (9814492)
PubChem (9860744)
PubChem (10613370)
PubChem (124338913)
PubChem (124399614)
PubChem (124426528)
PubChem (11889770)
PubChem (12358560)
PubChem (12358563)
PubChem (12358565)
PubChem (12358566)
PubChem (12358567)
PubChem (12358568)
PubChem (12358571)
PubChem (124896980)
PubChem (124904762)
PubChem (129317291)
PubChem (129606881)
PubChem (133556210)
PubChem (135033063)
PubChem (141834013)
PubChem (141888130)
PubChem (143972217)
PubChem (144612018)
PubChem (144878624)
PubChem (162900265)
PubChem (162900266)
PubChem (162900267)
PubChem (169544448)
Sequence modifications
A: 18 - 213 (PDB: 8YKD)
A: 214 - 394 (UniProt: P63091)
PDBExternal DatabaseDetails
Ala 236Gly 226conflict
Asp 259Ala 249conflict
Asp 262Ser 252conflict
-Asn 254deletion
-Met 255deletion
-Val 256deletion
-Ile 257deletion
-Arg 258deletion
-Glu 259deletion
-Asp 260deletion
-Asn 261deletion
-Gln 262deletion
-Thr 263deletion
Asp 272Leu 272conflict
Ser 366Ala 366conflict
Ala 372Ile 372conflict
Ile 375Val 375conflict
B: 2 - 340 (UniProt: P62871)
PDBExternal DatabaseDetails
Met -17-initiating methionine
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
G: -9 - 71 (UniProt: A0A7J7XNR4)
PDBExternal DatabaseDetails
Met -36-initiating methionine
Trp -35-expression tag
Arg -34-expression tag
Glu -33-expression tag
Leu -32-expression tag
Pro -31-expression tag
Leu -30-expression tag
Gly -29-expression tag
Leu -28-expression tag
Gly -27-expression tag
Glu -26-expression tag
Leu -25-expression tag
His -24-expression tag
Lys -23-expression tag
Asp -22-expression tag
His -21-expression tag
Gln -20-expression tag
Ala -19-expression tag
Ser -18-expression tag
Arg -17-expression tag
Lys -16-expression tag
Leu -15-expression tag
Glu -14-expression tag
Pro -13-expression tag
Glu -12-expression tag
Leu -11-expression tag
Trp -10-expression tag
R: 38 - 891 (UniProt: Q8CJ12)
PDBExternal DatabaseDetails
Met 14-initiating methionine
Lys 15-expression tag
Thr 16-expression tag
Ile 17-expression tag
Ile 18-expression tag
Ala 19-expression tag
Leu 20-expression tag
Ser 21-expression tag
Tyr 22-expression tag
Ile 23-expression tag
Phe 24-expression tag
Cys 25-expression tag
Leu 26-expression tag
Val 27-expression tag
Phe 28-expression tag
Ala 29-expression tag
Asp 30-expression tag
Tyr 31-expression tag
Lys 32-expression tag
Asp 33-expression tag
Asp 34-expression tag
Asp 35-expression tag
Asp 36-expression tag
Lys 37-expression tag
Ala 597His 597engineered mutation
Ala 599Thr 599engineered mutation
Phe 892-expression tag
Trp 893-expression tag
Phe 894-expression tag
Pro 895-expression tag
Glu 896-expression tag
Lys 897-expression tag
Gly 898-expression tag
Ala 899-expression tag
Ile 900-expression tag
Leu 901-expression tag
Thr 902-expression tag
Asp 903-expression tag
Thr 904-expression tag
Ser 905-expression tag
Val 906-expression tag
Lys 907-expression tag
Arg 908-expression tag
Asn 909-expression tag
Asp 910-expression tag
Leu 911-expression tag
Ser 912-expression tag
Ile 913-expression tag
Ile 914-expression tag
Ser 915-expression tag
Gly 916-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight232863.3
Non-Polymers*Number of molecules1
Total formula weight288.4
All*Total formula weight233151.8
*Water molecules are not included.

253389

PDB entries from 2026-05-13

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