8YK0
Cryo-EM structure of human GPR156-Gi3 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Probable G-protein coupled receptor 156 | polymer | 298 | 32797.1 | 1 | UniProt (Q8NFN8) Pfam (PF00003) | Homo sapiens (human) | G-protein coupled receptor PGR28,GABAB-related G-protein coupled receptor |
| 2 | B (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 338 | 37198.7 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 57 | 6289.2 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (domestic cattle) | G gamma-I |
| 4 | D (C) | Guanine nucleotide-binding protein G(i) subunit alpha-3 | polymer | 349 | 40078.5 | 1 | UniProt (P08754) Pfam (PF00503) | Homo sapiens (human) | G(i) alpha-3 |
| 5 | E (A) | Probable G-protein coupled receptor 156 | polymer | 317 | 35083.6 | 1 | UniProt (Q8NFN8) Pfam (PF00003) | Homo sapiens (human) | G-protein coupled receptor PGR28,GABAB-related G-protein coupled receptor |
| 6 | F, G, P, Q (B, A) | (21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate | non-polymer | 777.1 | 4 | Chemie (MW9) | |||
| 7 | H, I, J, K, L... (B, A) | CHOLESTEROL | non-polymer | 386.7 | 11 | Chemie (CLR) |
Sequence modifications
C: 6 - 354 (UniProt: P08754)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| Ser 326 | Ala 326 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 151447.1 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 7361.4 | |
| All* | Total formula weight | 158808.5 |
