8YJB
Cryo-EM structure of the human DSS1-INTAC complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 26S proteasome complex subunit DSS1 | polymer | 70 | 8284.6 | 1 | UniProt (P60896) Pfam (PF05160) | Homo sapiens (human) | Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein |
| 2 | B (I) | Integrator complex subunit 9 | polymer | 658 | 73891.2 | 1 | UniProt (Q9NV88) Pfam (PF16661) Pfam (PF10996) Pfam (PF21382) | Homo sapiens (human) | Int9,Protein related to CPSF subunits of 74 kDa,RC-74 |
| 3 | C (K) | Integrator complex subunit 11 | polymer | 600 | 67756.6 | 1 | UniProt (Q5TA45) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF21386) | Homo sapiens (human) | Int11,Cleavage and polyadenylation-specific factor 3-like protein,CPSF3-like protein,Protein related to CPSF subunits of 68 kDa,RC-68 |
| 4 | D (B) | Integrator complex subunit 2 | polymer | 1204 | 134451.6 | 1 | UniProt (Q9H0H0) Pfam (PF14750) | Homo sapiens (human) | Int2 |
| 5 | E (D) | Integrator complex subunit 4 | polymer | 963 | 108306.8 | 1 | UniProt (Q96HW7) Pfam (PF25458) Pfam (PF20168) Pfam (PF13646) Pfam (PF24493) | Homo sapiens (human) | Int4 |
| 6 | F (G) | Integrator complex subunit 7 | polymer | 962 | 106952.6 | 1 | UniProt (Q9NVH2) Pfam (PF24436) Pfam (PF24437) Pfam (PF22965) | Homo sapiens (human) | Int7 |
| 7 | G (P) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 589 | 65378.3 | 1 | UniProt (P30153) Pfam (PF02985) | Homo sapiens (human) | Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha |
| 8 | H (Q) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35636.2 | 1 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | PP2A-alpha,Replication protein C,RP-C |
| 9 | I (A) | Integrator complex subunit 1 | polymer | 2190 | 244574.9 | 1 | UniProt (Q8N201) Pfam (PF12432) Pfam (PF22929) Pfam (PF22927) Pfam (PF22928) | Homo sapiens (human) | Int1 |
| 10 | J (E) | Integrator complex subunit 5 | polymer | 1019 | 108115.2 | 1 | UniProt (Q6P9B9) Pfam (PF14837) Pfam (PF14838) | Homo sapiens (human) | Int5 |
| 11 | K (F) | Integrator complex subunit 6 | polymer | 887 | 100527.1 | 1 | UniProt (Q9UL03) Pfam (PF13519) Pfam (PF25462) Pfam (PF15300) | Homo sapiens (human) | Int6,DBI-1,Protein DDX26,Protein deleted in cancer 1,DICE1 |
| 12 | L (H) | Integrator complex subunit 8 | polymer | 995 | 113219.9 | 1 | UniProt (Q75QN2) Pfam (PF25756) | Homo sapiens (human) | Int8,Protein kaonashi-1 |
| 13 | M, N (K) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 14 | O, P (Q) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 1167095.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 240.7 | |
| All* | Total formula weight | 1167335.7 |
