8YG4
A cryo-EM structure of LA-PTH-R1-PTH1R-Gs complex structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha-1 | polymer | 361 | 41879.5 | 1 | Homo sapiens (human) | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 354 | 38526.0 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | NB35 | polymer | 140 | 15343.0 | 1 | Mus musculus | ||
| 5 | E (P) | LA-PTH-R1 | polymer | 32 | 3945.7 | 1 | Homo sapiens (human) | ||
| 6 | F (R) | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 476 | 54464.7 | 1 | UniProt (Q03431) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 162020.0 | |
| All* | Total formula weight | 162020.0 |
