8YD0
CryoEM structure of M. tuberculosis ClpXP1P2 complex bound to bortezomib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | ATP-dependent Clp protease ATP-binding subunit ClpX | polymer | 355 | 39057.8 | 6 | UniProt (P9WPB9) Pfam (PF07724) Pfam (PF10431) | Mycobacterium tuberculosis H37Rv | |
| 2 | G, H, I, J, K... (H, I, K, L, M...) | ATP-dependent Clp protease proteolytic subunit 2 | polymer | 196 | 21543.6 | 7 | UniProt (P9WPC3) Pfam (PF00574) | Mycobacterium tuberculosis H37Rv | Endopeptidase Clp 2 |
| 3 | M, N, O, P, Q... (O, P, Q, R, S...) | ATP-dependent Clp protease proteolytic subunit 1 | polymer | 178 | 19383.1 | 7 | UniProt (P9WPC5) Pfam (PF00574) | Mycobacterium tuberculosis H37Rv | Endopeptidase Clp 1 |
| 4 | AA, U (E, A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | V, W, X, Y (A, B, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 6 | BA, Z (F, E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 7 | CA, DA, EA, FA, GA... (H, I, K, L, M...) | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | non-polymer | 384.2 | 14 | Chemie (BO2) |
Sequence modifications
A, B, C, D, E, F: 60 - 414 (UniProt: P9WPB9)
| PDB | External Database | Details |
|---|---|---|
| Gln 187 | Glu 187 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 20 |
| Total formula weight | 520833.2 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 8311.1 | |
| All* | Total formula weight | 529144.3 |
