8Y81

Structure of the ige-fc bound to its high affinity receptor fc(epsilon)ri

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	High affinity immunoglobulin epsilon receptor subunit alpha	polymer	245	27830.2	1	UniProt (P12371) Pfam (PF13895)	Rattus norvegicus (Norway rat)	Fc-epsilon RI-alpha,FcERI,IgE Fc receptor subunit alpha
2	B (B)	High affinity immunoglobulin epsilon receptor subunit beta	polymer	243	26747.8	1	UniProt (P13386) Pfam (PF04103)	Rattus norvegicus (Norway rat)	FcERI,Fc epsilon receptor I beta-chain,IgE Fc receptor subunit beta
3	C, F (C, G)	High affinity immunoglobulin epsilon receptor subunit gamma	polymer	119	13459.3	2	UniProt (P20411) Pfam (PF11628) Pfam (PF02189)	Rattus norvegicus (Norway rat)	Fc receptor gamma-chain,FcRgamma,Fc-epsilon RI-gamma,IgE Fc receptor subunit gamma,FceRI gamma
4	D, E (E, F)	Immunoglobulin heavy constant epsilon	polymer	363	41815.4	2	UniProt (P01855) Pfam (PF07654) Pfam (PF00047)	Rattus norvegicus (Norway rat)	Ig epsilon chain C region
5	G, H (D, H)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
6	I (T)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	J, K, M, N, O (A, E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
8	L (B)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	1	Chemie (Y01)

Sequence modifications

C, G: 1 - 86 (UniProt: P20411)

PDB	External Database	Details
Gly 87	-	expression tag
Ser 88	-	expression tag
Gly 89	-	expression tag
Trp 90	-	expression tag
Ser 91	-	expression tag
His 92	-	expression tag
Pro 93	-	expression tag
Gln 94	-	expression tag
Phe 95	-	expression tag
Glu 96	-	expression tag
Lys 97	-	expression tag
Gly 98	-	expression tag
Ser 99	-	expression tag
Gly 100	-	expression tag
Asp 101	-	expression tag
Tyr 102	-	expression tag
Lys 103	-	expression tag
Asp 104	-	expression tag
Asp 105	-	expression tag
Asp 106	-	expression tag
Asp 107	-	expression tag
Lys 108	-	expression tag
Gly 109	-	expression tag
Ser 110	-	expression tag
Gly 111	-	expression tag
Trp 112	-	expression tag
Ser 113	-	expression tag
His 114	-	expression tag
Pro 115	-	expression tag
Gln 116	-	expression tag
Phe 117	-	expression tag
Glu 118	-	expression tag
Lys 119	-	expression tag

E, F: 95 - 429 (UniProt: P01855)

PDB	External Database	Details
Met 73	-	initiating methionine
Ser 74	-	expression tag
Val 75	-	expression tag
Pro 76	-	expression tag
Thr 77	-	expression tag
Gln 78	-	expression tag
Val 79	-	expression tag
Leu 80	-	expression tag
Gly 81	-	expression tag
Leu 82	-	expression tag
Leu 83	-	expression tag
Leu 84	-	expression tag
Leu 85	-	expression tag
Trp 86	-	expression tag
Leu 87	-	expression tag
Thr 88	-	expression tag
Asp 89	-	expression tag
Ala 90	-	expression tag
Arg 91	-	expression tag
Cys 92	-	expression tag
Asp 93	-	expression tag
Ile 94	-	expression tag
His 430	-	expression tag
His 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	165127.4
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	6
	Total formula weight	1592.8
All*	Total formula weight	168317.7

*Water molecules are not included.