8Y6W
TUG-1375 and 4-CMTB-bound human FFA2 in complex with Gi
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 357 | 39286.9 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (D) | scFv16 | polymer | 259 | 27784.9 | 1 | Mus musculus | ||
| 5 | E (R) | Free fatty acid receptor 2 | polymer | 362 | 40920.0 | 1 | UniProt (O15552) Pfam (PF00001) | Homo sapiens (human) | G-protein coupled receptor 43 |
| 6 | F (R) | (2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid | non-polymer | 442.9 | 1 | Chemie (9UJ) | |||
| 7 | G (R) | (2~{S})-2-(4-chlorophenyl)-3-methyl-~{N}-(1,3-thiazol-2-yl)butanamide | non-polymer | 294.8 | 1 | Chemie (A1LYC) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: 1 - 325 (UniProt: O15552)
| PDB | External Database | Details |
|---|---|---|
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -30 | - | initiating methionine |
| Lys -29 | - | expression tag |
| Thr -28 | - | expression tag |
| Ile -27 | - | expression tag |
| Ile -26 | - | expression tag |
| Ala -25 | - | expression tag |
| Leu -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Tyr -22 | - | expression tag |
| Ile -21 | - | expression tag |
| Phe -20 | - | expression tag |
| Cys -19 | - | expression tag |
| Leu -18 | - | expression tag |
| Val -17 | - | expression tag |
| Phe -16 | - | expression tag |
| Ala -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Tyr -13 | - | expression tag |
| Lys -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Asp -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Leu 326 | - | expression tag |
| Glu 327 | - | expression tag |
| Val 328 | - | expression tag |
| Leu 329 | - | expression tag |
| Phe 330 | - | expression tag |
| Gln 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 156267.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 737.7 | |
| All* | Total formula weight | 157005.6 |
