8Y60
Structural mechanism of human HCN1 hyperpolarization-activated channel inhibition by ivabradine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | polymer | 890 | 98899.8 | 4 | UniProt (O60741) Pfam (PF08412) Pfam (PF00520) Pfam (PF00027) | Homo sapiens (human) | Brain cyclic nucleotide-gated channel 1,BCNG-1 |
| 2 | E, G, I, K (A, B, C, D) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | Homo sapiens | ||
| 3 | F, H, J, L (A, B, C, D) | Ivabradine | non-polymer | 468.6 | 4 | Chemie (VNZ) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 395599.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3421.0 | |
| All* | Total formula weight | 399020.1 |
