8Y56
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Lysosomal cholesterol signaling protein | polymer | 840 | 93876.4 | 1 | UniProt (Q7Z3F1) Pfam (PF03547) Pfam (PF00610) | Homo sapiens (human) | LYCHOS,G-protein coupled receptor PGR22 |
| 2 | B (R) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C, D, E, F, G (R) | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
| 4 | H (R) | [(2R)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoate | non-polymer | 720.0 | 1 | Chemie (DKB) | |||
| 5 | I (R) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
R: 21 - 836 (UniProt: Q7Z3F1)
| PDB | External Database | Details |
|---|---|---|
| Met -3 | - | initiating methionine |
| Lys -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Ile 0 | - | expression tag |
| Ile 1 | - | expression tag |
| Ala 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Ser 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Ile 6 | - | expression tag |
| Phe 7 | - | expression tag |
| Cys 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Val 10 | - | expression tag |
| Phe 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Lys 15 | - | expression tag |
| Asp 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Lys 20 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 93876.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2676.3 | |
| All* | Total formula weight | 96552.6 |
