8Y53
Cryo-EM structure of the MK-5046-bound BRS3-Gq complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 361 | 41724.4 | 1 | Homo sapiens (human) | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (E) | scFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (N) | nanobody Nb35 | polymer | 150 | 16097.2 | 1 | Lama glama | ||
| 6 | F (R) | Bombesin receptor subtype-3 | polymer | 361 | 40518.2 | 1 | UniProt (P32247) Pfam (PF00001) | Homo sapiens (human) | BRS-3 |
| 7 | G (R) | (2~{S})-1,1,1-tris(fluoranyl)-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1~{H}-imidazol-2-yl]propan-2-ol | non-polymer | 444.4 | 1 | Chemie (A1D54) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 170393.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 444.4 | |
| All* | Total formula weight | 170838.1 |
