8Y45
Cryo-EM structure of opioid receptor with biased agonist
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Delta-type opioid receptor | polymer | 325 | 36174.0 | 1 | UniProt (P41143) Pfam (PF00001) | Homo sapiens (human) | D-OR-1,DOR-1 |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39336.0 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (D) | Guanine nucleotide-binding protein G(i) subunit alpha-2 | polymer | 355 | 40516.9 | 1 | UniProt (P04899) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (S) | scFv16 | polymer | 266 | 28636.8 | 1 | Mus musculus | ||
| 5 | E (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F (A) | ~{N},~{N}-diethyl-4-(5-oxidanylspiro[chromene-2,4'-piperidine]-4-yl)benzamide | non-polymer | 392.5 | 1 | Chemie (A1LXY) |
Sequence modifications
A: 36 - 352 (UniProt: P41143)
B: 2 - 340 (UniProt: P62873)
D: 1 - 355 (UniProt: P04899)
| PDB | External Database | Details |
|---|---|---|
| Asp 28 | - | expression tag |
| Tyr 29 | - | expression tag |
| Lys 30 | - | expression tag |
| Asp 31 | - | expression tag |
| Asp 32 | - | expression tag |
| Asp 33 | - | expression tag |
| Asp 34 | - | expression tag |
| Ala 35 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| Pro -16 | - | expression tag |
| Pro -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 5 | Val 5 | variant |
| Asn 47 | Ser 47 | conflict |
| Ala 204 | Gly 204 | conflict |
| Ala 246 | Glu 246 | conflict |
| Ser 327 | Ala 327 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 152524.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 152917.3 |
