8Y40
Structure of chimeric RyR-I4657M/G4819E complex with chlorantraniliprole
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (E, H, G, F) | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 107 | 11667.3 | 4 | UniProt (P68106) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 2 | B, D, F, H (I, L, K, J) | Calmodulin-1 | polymer | 149 | 16620.4 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | I, J, K, L (A, B, C, D) | Ryanodine receptor 1 | polymer | 5037 | 565970.6 | 4 | UniProt (P11716) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119) | Oryctolagus cuniculus (rabbit) | RYR-1,RyR1,Skeletal muscle calcium release channel,Skeletal muscle ryanodine receptor,Skeletal muscle-type ryanodine receptor,Type 1 ryanodine receptor |
| 4 | BA, M, R, W (D, A, B, C) | 5-bromanyl-N-[4-chloranyl-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloranylpyridin-2-yl)pyrazole-3-carboxamide | non-polymer | 483.1 | 4 | Chemie (F0U) | |||
| 5 | CA, N, S, X (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 6 | DA, O, T, Y (D, A, B, C) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 7 | EA, P, U, Z (D, A, B, C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 8 | AA, FA, Q, V (C, D, A, B) | CAFFEINE | non-polymer | 194.2 | 4 | Chemie (CFF) |
Sequence modifications
I, L, K, J: 1 - 149 (UniProt: P0DP23)
A, B, C, D: 1 - 5037 (UniProt: P11716)
| PDB | External Database | Details |
|---|---|---|
| Ala 32 | Glu 32 | engineered mutation |
| Ala 68 | Glu 68 | engineered mutation |
| Ala 105 | Glu 105 | engineered mutation |
| Ala 141 | Glu 141 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Lys 4563 | Arg 4563 | engineered mutation |
| Tyr 4564 | Phe 4564 | engineered mutation |
| Met 4657 | Cys 4657 | engineered mutation |
| Ser 4792 | Leu 4792 | engineered mutation |
| Glu 4819 | Gly 4819 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 2377033.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 5160.0 | |
| All* | Total formula weight | 2382193.1 |
