8Y38
Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | Large ribosomal subunit protein bL33B | polymer | 47 | 5684.6 | 1 | UniProt (P66232) Pfam (PF00471) | Staphylococcus aureus | 50S ribosomal protein L33 2 |
| 2 | B (2) | Large ribosomal subunit protein bL34 | polymer | 43 | 5252.4 | 1 | UniProt (P66254) Pfam (PF00468) | Staphylococcus aureus | 50S ribosomal protein L34 |
| 3 | C (3) | Large ribosomal subunit protein bL35 | polymer | 64 | 7462.0 | 1 | UniProt (P66277) Pfam (PF01632) | Staphylococcus aureus | 50S ribosomal protein L35 |
| 4 | D (4) | Large ribosomal subunit protein bL36 | polymer | 37 | 4318.4 | 1 | UniProt (P66300) Pfam (PF00444) | Staphylococcus aureus | 50S ribosomal protein L36 |
| 5 | E (A) | 23S ribosomal RNA | polymer | 2921 | 946121.2 | 1 | GenBank (1865318698) | Staphylococcus aureus | |
| 6 | F (B) | 5S ribosomal RNA | polymer | 115 | 36974.9 | 1 | GenBank (1760048038) | Staphylococcus aureus | |
| 7 | G (C) | Large ribosomal subunit protein uL2 | polymer | 274 | 29827.6 | 1 | UniProt (P60433) Pfam (PF00181) Pfam (PF03947) | Staphylococcus aureus | 50S ribosomal protein L2 |
| 8 | H (D) | Large ribosomal subunit protein uL3 | polymer | 215 | 23199.5 | 1 | UniProt (P60450) Pfam (PF00297) | Staphylococcus aureus | 50S ribosomal protein L3 |
| 9 | I (E) | Large ribosomal subunit protein uL4 | polymer | 206 | 22364.5 | 1 | UniProt (P61060) Pfam (PF00573) | Staphylococcus aureus | 50S ribosomal protein L4 |
| 10 | J (F) | Large ribosomal subunit protein uL5 | polymer | 175 | 19731.9 | 1 | UniProt (Q7A083) Pfam (PF00673) Pfam (PF00281) | Staphylococcus aureus | 50S ribosomal protein L5 |
| 11 | K (G) | Large ribosomal subunit protein uL6 | polymer | 175 | 19501.2 | 1 | UniProt (Q7A084) Pfam (PF00347) | Staphylococcus aureus | 50S ribosomal protein L6 |
| 12 | L (H) | Large ribosomal subunit protein uL13 | polymer | 145 | 16359.4 | 1 | UniProt (Q7A089) Pfam (PF00572) | Staphylococcus aureus | 50S ribosomal protein L13 |
| 13 | M (I) | Large ribosomal subunit protein uL14 | polymer | 122 | 13157.3 | 1 | UniProt (Q7A081) Pfam (PF00238) | Staphylococcus aureus | 50S ribosomal protein L14 |
| 14 | N (J) | Large ribosomal subunit protein uL15 | polymer | 146 | 15628.9 | 1 | UniProt (P0A0F7) Pfam (PF00828) | Staphylococcus aureus | 50S ribosomal protein L15 |
| 15 | O (K) | Large ribosomal subunit protein uL16 | polymer | 137 | 15599.4 | 1 | UniProt (Q7A080) Pfam (PF00252) | Staphylococcus aureus | 50S ribosomal protein L16 |
| 16 | P (L) | Large ribosomal subunit protein bL17 | polymer | 120 | 13583.5 | 1 | UniProt (Q7A087) Pfam (PF01196) | Staphylococcus aureus | 50S ribosomal protein L17 |
| 17 | Q (M) | Large ribosomal subunit protein uL18 | polymer | 119 | 13124.1 | 1 | UniProt (Q7A085) Pfam (PF00861) | Staphylococcus aureus | 50S ribosomal protein L18 |
| 18 | R (N) | Large ribosomal subunit protein bL19 | polymer | 114 | 13104.4 | 1 | UniProt (Q8NX05) Pfam (PF01245) | Staphylococcus aureus | 50S ribosomal protein L19 |
| 19 | S (O) | Large ribosomal subunit protein bL20 | polymer | 116 | 13459.9 | 1 | UniProt (P66109) Pfam (PF00453) | Staphylococcus aureus | 50S ribosomal protein L20 |
| 20 | T (P) | Large ribosomal subunit protein bL21 | polymer | 102 | 11354.1 | 1 | UniProt (Q7A0Q2) Pfam (PF00829) | Staphylococcus aureus | 50S ribosomal protein L21 |
| 21 | U (Q) | Large ribosomal subunit protein uL22 | polymer | 117 | 12857.9 | 1 | UniProt (Q7A079) Pfam (PF00237) | Staphylococcus aureus | 50S ribosomal protein L22 |
| 22 | V (R) | Large ribosomal subunit protein uL23 | polymer | 89 | 10380.1 | 1 | UniProt (Q7A078) Pfam (PF00276) | Staphylococcus aureus | 50S ribosomal protein L23 |
| 23 | W (S) | Large ribosomal subunit protein uL24 | polymer | 103 | 11316.2 | 1 | UniProt (P60736) Pfam (PF00467) Pfam (PF17136) | Staphylococcus aureus | 50S ribosomal protein L24 |
| 24 | X (T) | Large ribosomal subunit protein bL25 | polymer | 94 | 10462.2 | 1 | UniProt (Q7A1S4) Pfam (PF01386) | Staphylococcus aureus | 50S ribosomal protein L25,General stress protein CTC |
| 25 | Y (U) | Large ribosomal subunit protein bL27 | polymer | 82 | 8911.1 | 1 | UniProt (P66134) Pfam (PF01016) | Staphylococcus aureus | 50S ribosomal protein L27 |
| 26 | Z (V) | Large ribosomal subunit protein bL28 | polymer | 58 | 6550.7 | 1 | UniProt (P66154) Pfam (PF00830) | Staphylococcus aureus | 50S ribosomal protein L28 |
| 27 | AA (W) | Large ribosomal subunit protein uL29 | polymer | 67 | 7845.9 | 1 | UniProt (P66174) Pfam (PF00831) | Staphylococcus aureus | 50S ribosomal protein L29 |
| 28 | BA (X) | Large ribosomal subunit protein uL30 | polymer | 58 | 6434.5 | 1 | UniProt (P0A0G1) Pfam (PF00327) | Staphylococcus aureus | 50S ribosomal protein L30 |
| 29 | CA (Y) | Large ribosomal subunit protein bL31B | polymer | 59 | 6909.7 | 1 | UniProt (P66197) Pfam (PF01197) | Staphylococcus aureus | 50S ribosomal protein L31 type B |
| 30 | DA (Z) | Large ribosomal subunit protein bL32 | polymer | 48 | 5569.6 | 1 | UniProt (P66211) Pfam (PF01783) | Staphylococcus aureus | 50S ribosomal protein L32 |
| 31 | EA (a) | 16S ribosomal RNA | polymer | 1548 | 500724.6 | 1 | GenBank (1747281577) | Staphylococcus aureus | |
| 32 | FA (b) | Small ribosomal subunit protein uS2 | polymer | 232 | 26588.0 | 1 | UniProt (A0A2X2M020) Pfam (PF00318) | Staphylococcus aureus | 30S ribosomal protein S2 |
| 33 | GA (c) | Small ribosomal subunit protein uS3 | polymer | 217 | 24143.9 | 1 | UniProt (P66554) Pfam (PF07650) Pfam (PF00189) | Staphylococcus aureus | 30S ribosomal protein S3 |
| 34 | HA (d) | Small ribosomal subunit protein uS4 | polymer | 200 | 23051.4 | 1 | UniProt (P66564) Pfam (PF00163) Pfam (PF01479) | Staphylococcus aureus | 30S ribosomal protein S4 |
| 35 | IA (e) | Small ribosomal subunit protein uS5 | polymer | 166 | 17770.5 | 1 | UniProt (P66580) Pfam (PF00333) Pfam (PF03719) | Staphylococcus aureus | 30S ribosomal protein S5 |
| 36 | JA (f) | Small ribosomal subunit protein bS6 | polymer | 98 | 11613.1 | 1 | UniProt (P66596) Pfam (PF01250) | Staphylococcus aureus | 30S ribosomal protein S6 |
| 37 | KA (g) | Small ribosomal subunit protein uS7 | polymer | 156 | 17826.6 | 1 | UniProt (P66617) Pfam (PF00177) | Staphylococcus aureus | 30S ribosomal protein S7 |
| 38 | LA (h) | Small ribosomal subunit protein uS8 | polymer | 132 | 14854.3 | 1 | UniProt (P66631) Pfam (PF00410) | Staphylococcus aureus | 30S ribosomal protein S8 |
| 39 | MA (i) | Small ribosomal subunit protein uS9 | polymer | 130 | 14642.7 | 1 | UniProt (P66647) Pfam (PF00380) | Staphylococcus aureus | 30S ribosomal protein S9 |
| 40 | NA (j) | Small ribosomal subunit protein uS10 | polymer | 102 | 11598.5 | 1 | UniProt (P66335) Pfam (PF00338) | Staphylococcus aureus | 30S ribosomal protein S10 |
| 41 | OA (k) | Small ribosomal subunit protein uS11 | polymer | 129 | 13908.0 | 1 | UniProt (P66358) Pfam (PF00411) | Staphylococcus aureus | 30S ribosomal protein S11 |
| 42 | PA (l) | Small ribosomal subunit protein uS12 | polymer | 149 | 16813.6 | 1 | UniProt (A0A133PZQ5) | Staphylococcus aureus | 30S ribosomal protein S12 |
| 43 | QA (m) | Small ribosomal subunit protein uS13 | polymer | 121 | 13747.9 | 1 | UniProt (P66389) Pfam (PF00416) | Staphylococcus aureus | 30S ribosomal protein S13 |
| 44 | RA (n) | Small ribosomal subunit protein uS14B | polymer | 61 | 7317.8 | 1 | UniProt (P66413) Pfam (PF00253) | Staphylococcus aureus | 30S ribosomal protein S14 type Z |
| 45 | SA (o) | Small ribosomal subunit protein uS15 | polymer | 89 | 10634.3 | 1 | UniProt (Q7A116) Pfam (PF00312) | Staphylococcus aureus | 30S ribosomal protein S15 |
| 46 | TA (p) | Small ribosomal subunit protein bS16 | polymer | 91 | 10253.9 | 1 | UniProt (P66441) Pfam (PF00886) | Staphylococcus aureus | 30S ribosomal protein S16 |
| 47 | UA (q) | Small ribosomal subunit protein uS17 | polymer | 87 | 10196.9 | 1 | UniProt (Q8NVB4) Pfam (PF00366) | Staphylococcus aureus | 30S ribosomal protein S17 |
| 48 | VA (r) | Small ribosomal subunit protein bS18 | polymer | 80 | 9332.0 | 1 | UniProt (P66469) Pfam (PF01084) | Staphylococcus aureus | 30S ribosomal protein S18 |
| 49 | WA (s) | Small ribosomal subunit protein uS19 | polymer | 108 | 12319.3 | 1 | UniProt (A0A133PYC3) | Staphylococcus aureus | 30S ribosomal protein S19 |
| 50 | XA (t) | Small ribosomal subunit protein bS20 | polymer | 83 | 9039.5 | 1 | UniProt (Q7A0R9) Pfam (PF01649) | Staphylococcus aureus | 30S ribosomal protein S20 |
| 51 | YA (A) | 7-[4-[3-[[(1~{S},2~{R},5~{R},6~{S},7~{S},8~{R},9~{R},11~{R},13~{R},14~{R})-8-[(2~{S},3~{R},4~{S},6~{R})-4-(dimethylamino)-6-methyl-3-oxidanyl-oxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-tris(oxidanylidene)-3,17-dioxa-15-azabicyclo[12.3.0]heptadecan-6-yl]oxycarbonylamino]propoxy]but-1-ynyl]-1-methyl-4-oxidanylidene-quinoline-3-carboxylic acid | non-polymer | 969.1 | 1 | Chemie (A1D6G) | |||
| 52 | AB, BB, CB, DB, EB... (A) | MAGNESIUM ION | non-polymer | 24.3 | 12 | Chemie (MG) | |||
| 53 | LB (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
a: 5 - 1552 (GenBank: 1747281577)
| PDB | External Database | Details |
|---|---|---|
| N 1032 | C 428344 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 50 |
| Total formula weight | 2109424.0 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1260.8 | |
| All* | Total formula weight | 2110684.8 |
