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8Y22

FGFR1 kinase domain with a covalent inhibitor 9g

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1B, AFibroblast growth factor receptor 1polymer30835110.42UniProt (P11362)
Pfam (PF07714)
In PDB
Homo sapiens (human)FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2B, A~{N}-[4-[[4-azanyl-3-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]phenyl]propanamidenon-polymer472.62Chemie (A1LW9)
3B, ASULFATE IONnon-polymer96.17Chemie (SO4)
4waterwater18.038Chemie (HOH)
Sequence modifications
B, A: 458 - 765 (UniProt: P11362)
PDBExternal DatabaseDetails
Ser 584Cys 584engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70220.7
Non-Polymers*Number of molecules9
Total formula weight1617.6
All*Total formula weight71838.3
*Water molecules are not included.

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PDB entries from 2024-07-17

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