8Y22

FGFR1 kinase domain with a covalent inhibitor 9g

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Fibroblast growth factor receptor 1	polymer	308	35110.4	2	UniProt (P11362) Pfam (PF07714)	Homo sapiens (human)	FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2	C, H (B, A)	~{N}-[4-[[4-azanyl-3-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]phenyl]propanamide	non-polymer		472.6	2	Chemie (A1LW9)
3	D, E, F, G, I... (B, A)	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
4	L, M (B, A)	water	water		18.0	38	Chemie (HOH)

Sequence modifications

B, A: 458 - 765 (UniProt: P11362)

PDB	External Database	Details
Ser 584	Cys 584	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70220.7
Non-Polymers*	Number of molecules	9
	Total formula weight	1617.6
All*	Total formula weight	71838.3

*Water molecules are not included.