8Y21
Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadAB hetero-dimer from Mycobacterium tuberculosis complexed with substrate Palmitoyl-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (C, D) | (3R)-hydroxyacyl-ACP dehydratase subunit HadA | polymer | 164 | 18326.3 | 2 | UniProt (P9WFK1) Pfam (PF13452) | Mycobacterium tuberculosis H37Rv | |
| 2 | C, D (E, F) | (3R)-hydroxyacyl-ACP dehydratase subunit HadB | polymer | 142 | 14950.0 | 2 | UniProt (I6WYY7) Pfam (PF01575) | Mycobacterium tuberculosis H37Rv | |
| 3 | E, H (C, D) | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) | |||
| 4 | F, G, J, K, L (C, D, E) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) | |||
| 5 | I (D) | COENZYME A | non-polymer | 767.5 | 1 | Chemie (COA) | |||
| 6 | M, N, O, P (C, D, E, F) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 158 (UniProt: P9WFK1)
| PDB | External Database | Details |
|---|---|---|
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 66552.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1811.0 | |
| All* | Total formula weight | 68363.6 |
