8Y1V
Structure of GluN1b-GluN2D NMDA receptor in complex with competitive antagonist R-CPP and allosteric inhibitor YY-23
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Isoform 6 of Glutamate receptor ionotropic, NMDA 1 | polymer | 868 | 97777.9 | 2 | UniProt (Q05586) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Homo sapiens (human) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B, D (B, D) | Glutamate receptor ionotropic, NMDA 2D | polymer | 911 | 99057.3 | 2 | UniProt (O15399) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Homo sapiens (human) | GluN2D,EB11,Glutamate [NMDA] receptor subunit epsilon-4,N-methyl D-aspartate receptor subtype 2D,NMDAR2D,NR2D |
| 3 | E, F, H, I (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 4 | G, J (B, D) | (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[(2~{S})-2-methyl-4-[(1~{R},2~{R},4~{S},6~{S},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S},18~{R})-7,9,13,18-tetramethyl-16-oxidanyl-5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan-6-yl]butoxy]oxane-3,4,5-triol | non-polymer | 592.8 | 2 | Chemie (A1LW8) |
Sequence modifications
B, D: 1 - 879 (UniProt: O15399)
| PDB | External Database | Details |
|---|---|---|
| Ala 880 | - | expression tag |
| Ala 881 | - | expression tag |
| Ser 882 | - | expression tag |
| Ala 883 | - | expression tag |
| Trp 884 | - | expression tag |
| Ser 885 | - | expression tag |
| His 886 | - | expression tag |
| Pro 887 | - | expression tag |
| Gln 888 | - | expression tag |
| Phe 889 | - | expression tag |
| Glu 890 | - | expression tag |
| Lys 891 | - | expression tag |
| Gly 892 | - | expression tag |
| Gly 893 | - | expression tag |
| Gly 894 | - | expression tag |
| Ser 895 | - | expression tag |
| Gly 896 | - | expression tag |
| Gly 897 | - | expression tag |
| Gly 898 | - | expression tag |
| Ser 899 | - | expression tag |
| Gly 900 | - | expression tag |
| Gly 901 | - | expression tag |
| Ser 902 | - | expression tag |
| Ala 903 | - | expression tag |
| Trp 904 | - | expression tag |
| Ser 905 | - | expression tag |
| His 906 | - | expression tag |
| Pro 907 | - | expression tag |
| Gln 908 | - | expression tag |
| Phe 909 | - | expression tag |
| Glu 910 | - | expression tag |
| Lys 911 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 393670.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2070.4 | |
| All* | Total formula weight | 395740.9 |
