8XZF
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | R | Apelin receptor | polymer | 380 | 42696.3 | 1 | UniProt (P35414) Pfam (PF00001) In PDB | Homo sapiens (human) | Angiotensin receptor-like 1,G-protein coupled receptor APJ,G-protein coupled receptor HG11 |
| 2 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | |
| 4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 5 | S | scFv16 | polymer | 250 | 26610.6 | 1 | synthetic construct | ||
| 6 | L | WN561 | polymer | 14 | 1603.0 | 1 | synthetic construct |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| Ser 326 | Ala 326 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156470.8 | |
| All* | Total formula weight | 156470.8 |
