8XYD
Structure of Platelet-activating factor receptor-G protein complex bound to platelet-activating factor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet-activating factor receptor | polymer | 342 | 39242.3 | 1 | UniProt (P25105) Pfam (PF00001) | Homo sapiens (human) | PAF-R,PAFr |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37784.3 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (D) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 353 | 40313.9 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 5 | E (E) | scFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 6 | F (A) | (2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 523.7 | 1 | Chemie (PFS) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
D: 2 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 326 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 151181.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 523.7 | |
| All* | Total formula weight | 151705.2 |
