8XVI
Cryo-EM structure of ETAR bound with Endothelin1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 261 | 30464.3 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 346 | 38045.6 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody 35 | polymer | 157 | 17057.3 | 1 | Lama glama | ||
| 5 | E (R) | Endoglucanase H,Endothelin-1 receptor | polymer | 683 | 77879.4 | 1 | UniProt (P16218) UniProt (P25101) Pfam (PF02156) Pfam (PF00001) | Acetivibrio thermocellus ATCC 27405 | Cellulase H,Endo-1,4-beta-glucanase H,EgH,Endothelin receptor type A,ET-A,ETA-R,hET-AR |
| 6 | F (T) | Endothelin-1 | polymer | 21 | 2498.0 | 1 | UniProt (P05305) Pfam (PF00322) | Homo sapiens (human) | ET-1 |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: -229 - 49 (UniProt: P16218)
R: 50 - 405 (UniProt: P25101)
| PDB | External Database | Details |
|---|---|---|
| Ile -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Phe 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -259 | - | initiating methionine |
| Lys -258 | - | expression tag |
| Thr -257 | - | expression tag |
| Ile -256 | - | expression tag |
| Ile -255 | - | expression tag |
| Ala -254 | - | expression tag |
| Leu -253 | - | expression tag |
| Ser -252 | - | expression tag |
| Tyr -251 | - | expression tag |
| Ile -250 | - | expression tag |
| Phe -249 | - | expression tag |
| Cys -248 | - | expression tag |
| Leu -247 | - | expression tag |
| Val -246 | - | expression tag |
| Phe -245 | - | expression tag |
| Ala -244 | - | expression tag |
| Asp -243 | - | expression tag |
| Tyr -242 | - | expression tag |
| Lys -241 | - | expression tag |
| Asp -240 | - | expression tag |
| Asp -239 | - | expression tag |
| Asp -238 | - | expression tag |
| Asp -237 | - | expression tag |
| Ala -236 | - | expression tag |
| Gly -235 | - | expression tag |
| Arg -234 | - | expression tag |
| Ala -233 | - | expression tag |
| Met -232 | - | expression tag |
| Ala -231 | - | expression tag |
| Ser -230 | - | expression tag |
| Ala -124 | Glu 131 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 406 | - | expression tag |
| Glu 407 | - | expression tag |
| Val 408 | - | expression tag |
| Leu 409 | - | expression tag |
| Phe 410 | - | expression tag |
| Gln 411 | - | expression tag |
| Gly 412 | - | expression tag |
| Pro 413 | - | expression tag |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
| His 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 173805.7 | |
| All* | Total formula weight | 173805.7 |
