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8XT2

Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(L1)
16s rRNApolymer1559500019.61GenBank (1563835895)Homo sapiens (human)
2B
(L2)
Val tRNApolymer6922022.11GenBank (1858622516)Homo sapiens (human)
3C
(LB)
Large ribosomal subunit protein uL2mpolymer30533355.91UniProt (Q5T653)
Pfam (PF00181)
Pfam (PF03947)
Homo sapiens (human)39S ribosomal protein L2,mitochondrial,L2mt,MRP-L2
4D
(LC)
Large ribosomal subunit protein uL3mpolymer34838689.61UniProt (P09001)
Pfam (PF00297)
Homo sapiens (human)39S ribosomal protein L3,mitochondrial,L3mt,MRP-L3
5E
(LD)
Large ribosomal subunit protein uL4mpolymer31134970.21UniProt (Q9BYD3)
Pfam (PF00573)
Homo sapiens (human)39S ribosomal protein L4,mitochondrial,L4mt,MRP-L4
6F
(LI)
Large ribosomal subunit protein bL9mpolymer26730296.41UniProt (Q9BYD2)
Pfam (PF01281)
Pfam (PF22078)
Homo sapiens (human)39S ribosomal protein L9,mitochondrial,L9mt,MRP-L9
7G
(LJ)
Large ribosomal subunit protein uL10mpolymer26129322.51UniProt (Q7Z7H8)
Pfam (PF00466)
Homo sapiens (human)39S ribosomal protein L10,mitochondrial,L10mt,MRP-L10,39S ribosomal protein L8,L8mt,MRP-L8
8H
(LK)
Large ribosomal subunit protein uL11mpolymer19220716.21UniProt (Q9Y3B7)
Pfam (PF03946)
Pfam (PF00298)
Homo sapiens (human)39S ribosomal protein L11,mitochondrial,L11mt,MRP-L11
9I
(LM)
Large ribosomal subunit protein uL13mpolymer17820723.01UniProt (Q9BYD1)
Pfam (PF00572)
Homo sapiens (human)39S ribosomal protein L13,mitochondrial,L13mt,MRP-L13
10J
(LN)
Large ribosomal subunit protein uL14mpolymer14515973.71UniProt (Q6P1L8)
Pfam (PF00238)
Homo sapiens (human)39S ribosomal protein L14,mitochondrial,L14mt,MRP-L14,39S ribosomal protein L32,L32mt,MRP-L32
11K
(LO)
Large ribosomal subunit protein uL15mpolymer29633473.81UniProt (Q9P015)
Pfam (PF00828)
Homo sapiens (human)39S ribosomal protein L15,mitochondrial,L15mt,MRP-L15
12L
(LP)
Large ribosomal subunit protein uL16mpolymer25128496.31UniProt (Q9NX20)
Pfam (PF00252)
Homo sapiens (human)39S ribosomal protein L16,mitochondrial,L16mt,MRP-L16
13M
(LQ)
Large ribosomal subunit protein bL17mpolymer17520083.31UniProt (Q9NRX2)
Pfam (PF01196)
Homo sapiens (human)39S ribosomal protein L17,mitochondrial,L17mt,MRP-L17,LYST-interacting protein 2
14N
(LR)
Mitochondrial ribosomal protein L18, isoform CRA_bpolymer17920465.31UniProt (A8K9D2)
Pfam (PF00861)
UniProt (by SIFTS) (Q9H0U6)
Homo sapiens (human)cDNA FLJ76688,highly similar to Homo sapiens HSPC071 mRNA
15O
(LS)
Large ribosomal subunit protein bL19mpolymer29233585.01UniProt (P49406)
Pfam (PF01245)
Homo sapiens (human)39S ribosomal protein L15,mitochondrial,L15mt,MRP-L15,39S ribosomal protein L19,L19mt,MRP-L19
16P
(LT)
Large ribosomal subunit protein bL20mpolymer14917479.71UniProt (Q9BYC9)
Pfam (PF00453)
Homo sapiens (human)39S ribosomal protein L20,mitochondrial,L20mt,MRP-L20
17Q
(LU)
Large ribosomal subunit protein bL21mpolymer20522847.71UniProt (Q7Z2W9)
Pfam (PF00829)
Homo sapiens (human)39S ribosomal protein L21,mitochondrial,L21mt,MRP-L21
18R
(LV)
39S ribosomal protein L22, mitochondrialpolymer21224369.51UniProt (E7ESL0)
Pfam (PF00237)
UniProt (by SIFTS) (Q9NWU5)
Homo sapiens (human)
19S
(LW)
Large ribosomal subunit protein uL23mpolymer15317807.21UniProt (Q16540)
Pfam (PF00276)
Homo sapiens (human)39S ribosomal protein L23,mitochondrial,L23mt,MRP-L23,L23 mitochondrial-related protein,Ribosomal protein L23-like
20T
(LX)
Large ribosomal subunit protein uL24mpolymer21624953.91UniProt (Q96A35)
Pfam (PF00467)
Pfam (PF17136)
Homo sapiens (human)39S ribosomal protein L24,mitochondrial,L24mt,MRP-L24
21U
(La)
Large ribosomal subunit protein bL27mpolymer14816102.91UniProt (Q9P0M9)
Pfam (PF01016)
Homo sapiens (human)39S ribosomal protein L27,mitochondrial,L27mt,MRP-L27
22V
(Lb)
Large ribosomal subunit protein bL28mpolymer25630202.91UniProt (Q13084)
Pfam (PF00830)
Homo sapiens (human)39S ribosomal protein L28,mitochondrial,L28mt,MRP-L28,Melanoma antigen p15,Melanoma-associated antigen recognized by T-lymphocytes
23W
(Lu)
Large ribosomal subunit protein uL29mpolymer25029508.51UniProt (Q9HD33)
Pfam (PF06984)
Homo sapiens (human)39S ribosomal protein L47,mitochondrial,L47mt,MRP-L47,Nasopharyngeal carcinoma metastasis-related protein 1
24X
(Ld)
Large ribosomal subunit protein uL30mpolymer16118582.81UniProt (Q8TCC3)
Pfam (PF00327)
Homo sapiens (human)39S ribosomal protein L28,mitochondrial,L28mt,MRP-L28,39S ribosomal protein L30,L30mt,MRP-L30
25Y
(Lf)
Large ribosomal subunit protein bL32mpolymer18821437.81UniProt (Q9BYC8)
Pfam (PF01783)
Homo sapiens (human)39S ribosomal protein L32,mitochondrial,L32mt,MRP-L32
26Z
(Lg)
Large ribosomal subunit protein bL33mpolymer657635.21UniProt (O75394)
Pfam (PF00471)
Homo sapiens (human)39S ribosomal protein L33,mitochondrial,L33mt,MRP-L33
27AA
(Lh)
Large ribosomal subunit protein bL34mpolymer9210183.91UniProt (Q9BQ48)
Pfam (PF00468)
Homo sapiens (human)39S ribosomal protein L34,mitochondrial,L34mt,MRP-L34
28BA
(Li)
Large ribosomal subunit protein bL35mpolymer18821558.51UniProt (Q9NZE8)
Pfam (PF01632)
Homo sapiens (human)39S ribosomal protein L35,mitochondrial,L35mt,MRP-L35
29CA
(Lj)
Large ribosomal subunit protein bL36mpolymer10311809.31UniProt (Q9P0J6)
Pfam (PF00444)
Homo sapiens (human)39S ribosomal protein L36,mitochondrial,L36mt,MRP-L36,BRCA1-interacting protein 1
30DA
(Lk)
Large ribosomal subunit protein mL37polymer42348183.31UniProt (Q9BZE1)
Pfam (PF07147)
Homo sapiens (human)39S ribosomal protein L2,mitochondrial,L2mt,MRP-L2,39S ribosomal protein L37,L37mt,MRP-L37
31EA
(Ll)
Large ribosomal subunit protein mL38polymer38044659.41UniProt (Q96DV4)
Pfam (PF01161)
Homo sapiens (human)39S ribosomal protein L38,mitochondrial,L38mt,MRP-L38
32FA
(Lm)
Large ribosomal subunit protein mL39polymer33838764.81UniProt (Q9NYK5)Homo sapiens (human)39S ribosomal protein L39,mitochondrial,L39mt,MRP-L39,39S ribosomal protein L5,L5mt,MRP-L5
33GA
(Ln)
Large ribosomal subunit protein mL40polymer20624534.41UniProt (Q9NQ50)
Pfam (PF09812)
Homo sapiens (human)39S ribosomal protein L40,mitochondrial,L40mt,MRP-L40,Nuclear localization signal-containing protein deleted in velocardiofacial syndrome,Up-regulated in metastasis
34HA
(Lo)
Large ribosomal subunit protein mL41polymer13715404.71UniProt (Q8IXM3)
Pfam (PF09809)
Homo sapiens (human)39S ribosomal protein L41,mitochondrial,L41mt,MRP-L41,Bcl-2-interacting mitochondrial ribosomal protein L41,Cell proliferation-inducing gene 3 protein,MRP-L27 homolog
35IA
(Lp)
Large ribosomal subunit protein mL42polymer14216691.21UniProt (Q9Y6G3)
Pfam (PF10210)
Homo sapiens (human)39S ribosomal protein L31,mitochondrial,L31mt,MRP-L31,39S ribosomal protein L42,L42mt,MRP-L42
36JA
(Lq)
Large ribosomal subunit protein mL43polymer21523457.81UniProt (Q8N983)
Pfam (PF05047)
Homo sapiens (human)39S ribosomal protein L43,mitochondrial,L43mt,MRP-L43,Mitochondrial ribosomal protein bMRP36a
37KA
(Lr)
Large ribosomal subunit protein mL44polymer33237583.31UniProt (Q9H9J2)
Pfam (PF22935)
Pfam (PF22892)
Homo sapiens (human)39S ribosomal protein L44,mitochondrial,L44mt,MRP-L44
38LA
(Ls)
Large ribosomal subunit protein mL45polymer30635402.91UniProt (Q9BRJ2)
Pfam (PF04280)
Homo sapiens (human)39S ribosomal protein L45,mitochondrial,L45mt,MRP-L45
39MA
(Lt)
Large ribosomal subunit protein mL46polymer27931748.11UniProt (Q9H2W6)
Pfam (PF11788)
Homo sapiens (human)39S ribosomal protein L46,mitochondrial,L46mt,MRP-L46,P2ECSL
40NA
(Lv)
Large ribosomal subunit protein mL48polymer21223970.81UniProt (Q96GC5)
Pfam (PF00338)
Homo sapiens (human)39S ribosomal protein L48,mitochondrial,L48mt,MRP-L48
41OA
(Lw)
Large ribosomal subunit protein mL49polymer16619225.01UniProt (Q13405)
Pfam (PF05046)
Homo sapiens (human)39S ribosomal protein L49,mitochondrial,L49mt,MRP-L49,Neighbor of FAU,NOF,Protein NOF1
42PA
(Lx)
Large ribosomal subunit protein mL50polymer15818349.91UniProt (Q8N5N7)
Pfam (PF10501)
Homo sapiens (human)39S ribosomal protein L50,mitochondrial,L50mt,MRP-L50
43QA
(Ly)
Large ribosomal subunit protein mL51polymer12815125.91UniProt (Q4U2R6)
Pfam (PF10244)
Homo sapiens (human)39S ribosomal protein L51,mitochondrial,L51mt,MRP-L51,bMRP-64,bMRP64
44RA
(Lz)
39S ribosomal protein L52, mitochondrialpolymer12313696.71UniProt (A8K7J6)
Pfam (PF18699)
UniProt (by SIFTS) (Q86TS9)
Homo sapiens (human)
45SA
(L3)
Large ribosomal subunit protein mL53polymer11212125.91UniProt (Q96EL3)
Pfam (PF10780)
Homo sapiens (human)39S ribosomal protein L53,mitochondrial,L53mt,MRP-L53
46TA
(L4)
Large ribosomal subunit protein mL54polymer13815844.21UniProt (Q6P161)
Pfam (PF08561)
Homo sapiens (human)39S ribosomal protein L54,mitochondrial,L54mt,MRP-L54
47UA
(L5)
Large ribosomal subunit protein mL55polymer12815160.41UniProt (Q7Z7F7)
Pfam (PF09776)
Homo sapiens (human)39S ribosomal protein L55,mitochondrial,L55mt,MRP-L55,Mitochondrial large ribosomal subunit protein bL31m
48VA
(L6)
Large ribosomal subunit protein mL63polymer10212292.31UniProt (Q9BQC6)
Pfam (PF14978)
Homo sapiens (human)Mitochondrial ribosomal protein 63,Mitochondrial ribosomal protein L57,Ribosomal protein 63,mitochondrial,hMRP63
49WA
(L7)
Large ribosomal subunit protein mL62polymer20623674.21UniProt (Q14197)
Pfam (PF00472)
Homo sapiens (human)39S ribosomal protein L58,mitochondrial,MRP-L58,Digestion substraction 1,DS-1,Immature colon carcinoma transcript 1 protein,Peptidyl-tRNA hydrolase ICT1
50XA
(L8)
Large ribosomal subunit protein mL64polymer22225426.91UniProt (Q8TAE8)
Pfam (PF10147)
Homo sapiens (human)39S ribosomal protein L59,mitochondrial,MRP-L59,CKII beta-associating protein,CR6-interacting factor 1,CRIF1,Growth arrest and DNA damage-inducible proteins-interacting protein 1,Papillomavirus L2-interacting nuclear protein 1,PLINP,PLINP-1,p53-responsive gene 6 protein
51YA
(SR)
Large ribosomal subunit protein mL66polymer19622224.11UniProt (Q9NVS2)
Pfam (PF01084)
Homo sapiens (human)39S ribosomal protein S18-3,mitochondrial,MRP-S18-3,39S ribosomal protein S18a,MRP-S18-a,Mrps18a,S18mt-a,Large ribosomal subunit protein bS18a
52ZA
(Sf)
Large ribosomal subunit protein mL65polymer43950429.61UniProt (Q9NP92)
Pfam (PF07147)
Homo sapiens (human)39S ribosomal protein S30,mitochondrial,MRP-S30,S30mt,Large ribosomal subunit protein mS30,Programmed cell death protein 9
53AB
(SB)
Small ribosomal subunit protein uS2mpolymer29633298.21UniProt (Q9Y399)
Pfam (PF00318)
Homo sapiens (human)28S ribosomal protein S2,mitochondrial,MRP-S2,S2mt
54BB
(SZ)
Small ribosomal subunit protein uS3mpolymer16719046.21UniProt (Q96EL2)
Pfam (PF14955)
Homo sapiens (human)28S ribosomal protein S24,mitochondrial,MRP-S24,S24mt,bMRP-47,bMRP47
55CB
(SE)
Small ribosomal subunit protein uS5mpolymer43048094.61UniProt (P82675)
Pfam (PF21251)
Pfam (PF00333)
Pfam (PF03719)
Homo sapiens (human)28S ribosomal protein S5,mitochondrial,MRP-S5,S5mt
56DB
(SF)
Small ribosomal subunit protein bS6mpolymer12514250.61UniProt (P82932)
Pfam (PF01250)
Homo sapiens (human)28S ribosomal protein S6,mitochondrial,MRP-S6,S6mt
57EB
(SG)
Small ribosomal subunit protein uS7mpolymer24228186.21UniProt (Q9Y2R9)
Pfam (PF00177)
Homo sapiens (human)28S ribosomal protein S7,mitochondrial,MRP-S7,S7mt,bMRP-27a,bMRP27a
58FB
(SI)
Small ribosomal subunit protein uS9mpolymer39645909.91UniProt (P82933)
Pfam (PF00380)
Homo sapiens (human)28S ribosomal protein S9,mitochondrial,MRP-S9,S9mt
59GB
(SJ)
Small ribosomal subunit protein uS10mpolymer20123033.51UniProt (P82664)
Pfam (PF00338)
Homo sapiens (human)28S ribosomal protein S10,mitochondrial,MRP-S10,S10mt
60HB
(SK)
Small ribosomal subunit protein uS11mpolymer19420648.81UniProt (P82912)
Pfam (PF00411)
Homo sapiens (human)28S ribosomal protein S11,mitochondrial,MRP-S11,S11mt,Cervical cancer proto-oncogene 2 protein,HCC-2
61IB
(SL)
Small ribosomal subunit protein uS12mpolymer13815200.91UniProt (O15235)
Pfam (PF00164)
Homo sapiens (human)28S ribosomal protein S12,mitochondrial,MRP-S12,S12mt,MT-RPS12
62JB
(SN)
Small ribosomal subunit protein uS14mpolymer12815168.81UniProt (O60783)
Pfam (PF00253)
Homo sapiens (human)28S ribosomal protein S14,mitochondrial,MRP-S14,S14mt
63KB
(SO)
Small ribosomal subunit protein uS15mpolymer25729903.31UniProt (P82914)
Pfam (PF00312)
Homo sapiens (human)28S ribosomal protein S15,mitochondrial,MRP-S15,S15mt
64LB
(SP)
Small ribosomal subunit protein bS16mpolymer13715371.91UniProt (Q9Y3D3)
Pfam (PF00886)
Homo sapiens (human)28S ribosomal protein S16,mitochondrial,MRP-S16,S16mt
65MB
(SQ)
Small ribosomal subunit protein uS17mpolymer13014526.11UniProt (Q9Y2R5)
Pfam (PF00366)
Homo sapiens (human)28S ribosomal protein S17,mitochondrial,MRP-S17,S17mt
66NB
(SS)
Small ribosomal subunit protein mS40polymer25829440.61UniProt (Q9Y676)
Pfam (PF01084)
Homo sapiens (human)28S ribosomal protein S18-2,mitochondrial,MRP-S18-2,28S ribosomal protein S18b,MRP-S18-b,Mrps18-b,S18mt-b,Small ribosomal subunit protein bS18b
67OB
(ST)
Small ribosomal subunit protein bS18mpolymer14215876.81UniProt (Q9Y3D5)
Pfam (PF01084)
Homo sapiens (human)28S ribosomal protein S18-1,mitochondrial,MRP-S18-1,28S ribosomal protein S18c,MRP-S18-c,Mrps18-c,S18mt-c,Small ribosomal subunit protein bS18c
68PB
(SW)
Small ribosomal subunit protein bS21mpolymer8710764.71UniProt (P82921)
Pfam (PF01165)
Homo sapiens (human)28S ribosomal protein S21,mitochondrial,MRP-S21,S21mt
69QB
(SX)
Small ribosomal subunit protein mS22polymer36041337.31UniProt (P82650)
Pfam (PF10245)
Homo sapiens (human)28S ribosomal protein S22,mitochondrial,MRP-S22,S22mt
70RB
(SY)
Small ribosomal subunit protein mS23polymer19021805.71UniProt (Q9Y3D9)
Pfam (PF10484)
Homo sapiens (human)28S ribosomal protein S23,mitochondrial,MRP-S23,S23mt
71SB
(Sa)
Small ribosomal subunit protein mS25polymer17320146.41UniProt (P82663)
Pfam (PF05047)
Homo sapiens (human)28S ribosomal protein S25,mitochondrial,MRP-S25,S25mt
72TB
(Sb)
Small ribosomal subunit protein mS26polymer20524259.81UniProt (Q9BYN8)
Pfam (PF14943)
Homo sapiens (human)28S ribosomal protein S13,mitochondrial,MRP-S13,S13mt,28S ribosomal protein S26,MRP-S26,S26mt
73UB
(Sc)
Small ribosomal subunit protein mS27polymer41447669.31UniProt (Q92552)
Pfam (PF10037)
Homo sapiens (human)28S ribosomal protein S27,mitochondrial,MRP-S27,S27mt,Mitochondrial ribosomal protein S27
74VB
(Sd)
Small ribosomal subunit protein bS1mpolymer18720878.81UniProt (Q9Y2Q9)
Pfam (PF10246)
Homo sapiens (human)28S ribosomal protein S28,mitochondrial,MRP-S28,S28mt,28S ribosomal protein S35,MRP-S35,S35mt
75WB
(Se)
Small ribosomal subunit protein mS29polymer39845634.41UniProt (P51398)
Pfam (PF10236)
Homo sapiens (human)28S ribosomal protein S29,mitochondrial,MRP-S29,S29mt,Death-associated protein 3,DAP-3,Ionizing radiation resistance conferring protein
76XB
(Sg)
Small ribosomal subunit protein mS31polymer39545391.51UniProt (Q92665)
Pfam (PF15433)
Homo sapiens (human)28S ribosomal protein S31,mitochondrial,MRP-S31,S31mt,Imogen 38
77YB
(Si)
Small ribosomal subunit protein mS33polymer10612657.81UniProt (Q9Y291)
Pfam (PF08293)
Homo sapiens (human)28S ribosomal protein S33,mitochondrial,MRP-S33,S33mt
78ZB
(Sj)
Small ribosomal subunit protein mS34polymer21825695.51UniProt (P82930)
Pfam (PF16053)
Homo sapiens (human)28S ribosomal protein S34,mitochondrial,MRP-S34,S34mt
79AC
(Sk)
Small ribosomal subunit protein mS35polymer32336898.31UniProt (P82673)
Pfam (PF10213)
Homo sapiens (human)28S ribosomal protein S28,mitochondrial,MRP-S28,S28mt,28S ribosomal protein S35,MRP-S35,S35mt
80BC
(Sm)
Small ribosomal subunit protein mS37polymer11813498.81UniProt (Q96BP2)
Pfam (PF06747)
Homo sapiens (human)28S ribosomal protein S37,mitochondrial,MRP-S37,Coiled-coil-helix-coiled-coil-helix domain-containing protein 1,Nuclear protein C2360
81CC
(Sn)
Small ribosomal subunit protein mS38polymer19922395.31UniProt (Q9NWT8)
Pfam (PF08213)
Homo sapiens (human)28S ribosomal protein S38,mitochondrial,MRP-S38,Aurora kinase A-interacting protein,AURKA-interacting protein
82DC
(So)
Small ribosomal subunit protein mS39polymer68978648.51UniProt (Q96EY7)
Pfam (PF22330)
Pfam (PF13812)
Homo sapiens (human)28S ribosomal protein S39,mitochondrial,MRP-S39,Pentatricopeptide repeat domain-containing protein 3,Transformation-related gene 15 protein,TRG-15
83EC
(S1)
12s rRNApolymer954306135.21GenBank (587653826)Homo sapiens (human)
84AD, AE, AF, AG, AH...
(L1, S1, LB, LC, LP...)
MAGNESIUM IONnon-polymer24.3145Chemie (MG)
85EI, FG, GG
(S1, L1)
TIGECYCLINEnon-polymer587.73Chemie (T1C)
86NG, OG, RG, SG, TG...
(Lf, Lj, SR, SB, SS...)
ZINC IONnon-polymer65.47Chemie (ZN)
87WG
(Se)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
Sequence modifications
SW: 1 - 87 (UniProt: P82921)
PDBExternal DatabaseDetails
Arg 50Cys 50variant
S1: 1 - 954 (GenBank: 587653826)
PDBExternal DatabaseDetails
A 873U 1069conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains83
Total formula weight2882422.3
Non-Polymers*Number of molecules156
Total formula weight6188.3
All*Total formula weight2888610.6
*Water molecules are not included.

227344

PDB entries from 2024-11-13

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