8XSB
Crystal structure of the DNA-bound AHR-ARNT heterodimer in complex with Indirubin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aryl hydrocarbon receptor nuclear translocator | polymer | 382 | 43231.1 | 1 | UniProt (P27540) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) | Homo sapiens (human) | ARNT protein |
| 2 | B (B) | Aryl hydrocarbon receptor | polymer | 395 | 45242.7 | 1 | UniProt (I3LF82) Pfam (PF00010) Pfam (PF00989) Pfam (PF08447) | Sus scrofa (pig) | |
| 3 | C (C) | DNAF | polymer | 21 | 6473.2 | 1 | Homo sapiens | ||
| 4 | D (D) | DNAR | polymer | 21 | 6415.1 | 1 | Homo sapiens | ||
| 5 | E (B) | (3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one | non-polymer | 262.3 | 1 | Chemie (JY6) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 85 - 465 (UniProt: P27540)
B: 26 - 413 (UniProt: I3LF82)
| PDB | External Database | Details |
|---|---|---|
| Met 84 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 25 | - | initiating methionine |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| His 417 | - | expression tag |
| His 418 | - | expression tag |
| His 419 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101362.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 262.3 | |
| All* | Total formula weight | 101624.4 |
