8XQO
Structure of human class T GPCR TAS2R14-Gi complex with Aristolochic acid A.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 370 | 42425.1 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 366 | 39728.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | S | scFv16 | polymer | 286 | 30668.2 | 1 | Homo sapiens (human) | ||
5 | R | Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT | polymer | 990 | 110840.0 | 1 | UniProt (Q59310) UniProt (Q9NYV8) Pfam (PF13859) Pfam (PF05296) In PDB | Clostridium perfringens | Bitter taste receptor T2R14,T2R14,Taste receptor family B member 1,TRB1 |
6 | R | 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid | non-polymer | 341.3 | 1 | Chemie (GOQ) | |||
7 | R | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 1 - 340 (UniProt: P62873)
R: -455 - -4 (UniProt: Q59310)
R: 2 - 317 (UniProt: Q9NYV8)
R: 318 - 490 (PDB: 8XQO)
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
Asp -14 | - | expression tag |
Tyr -13 | - | expression tag |
Lys -12 | - | expression tag |
Asp -11 | - | expression tag |
Asp -10 | - | expression tag |
Asp -9 | - | expression tag |
Asp -8 | - | expression tag |
Lys -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -499 | - | initiating methionine |
Lys -498 | - | expression tag |
Thr -497 | - | expression tag |
Ile -496 | - | expression tag |
Ile -495 | - | expression tag |
Ala -494 | - | expression tag |
Leu -493 | - | expression tag |
Ser -492 | - | expression tag |
Tyr -491 | - | expression tag |
Ile -490 | - | expression tag |
Phe -489 | - | expression tag |
Cys -488 | - | expression tag |
Leu -487 | - | expression tag |
Val -486 | - | expression tag |
Phe -485 | - | expression tag |
Ala -484 | - | expression tag |
Asp -483 | - | expression tag |
Tyr -482 | - | expression tag |
Lys -481 | - | expression tag |
Asp -480 | - | expression tag |
Asp -479 | - | expression tag |
Asp -478 | - | expression tag |
Asp -477 | - | expression tag |
Ala -476 | - | expression tag |
His -475 | - | expression tag |
His -474 | - | expression tag |
His -473 | - | expression tag |
His -472 | - | expression tag |
His -471 | - | expression tag |
His -470 | - | expression tag |
His -469 | - | expression tag |
His -468 | - | expression tag |
His -467 | - | expression tag |
His -466 | - | expression tag |
Glu -465 | - | expression tag |
Asn -464 | - | expression tag |
Leu -463 | - | expression tag |
Tyr -462 | - | expression tag |
Phe -461 | - | expression tag |
Gln -460 | - | expression tag |
Ser -459 | - | expression tag |
Gly -458 | - | expression tag |
Arg -457 | - | expression tag |
Ala -456 | - | expression tag |
Ser -305 | Gly 393 | conflict |
Gly -3 | - | linker |
Ser -2 | - | linker |
Ala -1 | - | linker |
Gly 0 | - | linker |
Ser 1 | - | linker |
R: 318 - 490 (PDB: 8XQO)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 231522.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 727.9 | |
All* | Total formula weight | 232250.9 |