8XQI

Cryo-EM structure of human dimeric Apelin receptor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Soluble cytochrome b562,Apelin receptor	polymer	477	54312.6	2	UniProt (P0ABE7) UniProt (P35414) Pfam (PF00001)	Homo sapiens (human)	Cytochrome b-562,Angiotensin receptor-like 1,G-protein coupled receptor APJ,G-protein coupled receptor HG11
2	C, D (A, B)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)

Sequence modifications

A, B: -104 - 0 (UniProt: P0ABE7)

PDB	External Database	Details
Met -146	-	initiating methionine
Lys -145	-	expression tag
Thr -144	-	expression tag
Ile -143	-	expression tag
Ile -142	-	expression tag
Ala -141	-	expression tag
Leu -140	-	expression tag
Ser -139	-	expression tag
Tyr -138	-	expression tag
Ile -137	-	expression tag
Phe -136	-	expression tag
Cys -135	-	expression tag
Leu -134	-	expression tag
Val -133	-	expression tag
Phe -132	-	expression tag
Ala -131	-	expression tag
Asp -130	-	expression tag
Tyr -129	-	expression tag
Lys -128	-	expression tag
Asp -127	-	expression tag
Asp -126	-	expression tag
Asp -125	-	expression tag
Asp -124	-	expression tag
Lys -123	-	expression tag
His -122	-	expression tag
His -121	-	expression tag
His -120	-	expression tag
His -119	-	expression tag
His -118	-	expression tag
His -117	-	expression tag
His -116	-	expression tag
His -115	-	expression tag
His -114	-	expression tag
His -113	-	expression tag
Leu -112	-	expression tag
Glu -111	-	expression tag
Val -110	-	expression tag
Leu -109	-	expression tag
Phe -108	-	expression tag
Gln -107	-	expression tag
Gly -106	-	expression tag
Pro -105	-	expression tag
Trp -98	Met 29	conflict
Ile -3	His 124	conflict

A, B: 1 - 330 (UniProt: P35414)

PDB	External Database	Details
Leu 1	Met 1	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108625.2
Non-Polymers*	Number of molecules	2
	Total formula weight	773.3
All*	Total formula weight	109398.5

*Water molecules are not included.