8XQ2

Crystal structure of spleen tyrosine kinase(SYK)in complex with SKI-G-1693

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase SYK	polymer	290	33901.0	2	UniProt (P43405) Pfam (PF07714)	Homo sapiens (human)	Spleen tyrosine kinase,p72-Syk
2	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	D, E (A, B)	cyclopropyl-[1-(2-fluoranylethyl)-5-[[4-[4-[[(3~{R},4~{S})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]indol-3-yl]methanone	non-polymer		533.6	2	Chemie (A1LV7)
4	F, G (A, B)	water	water		18.0	142	Chemie (HOH)

Sequence modifications

A, B: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Leu 636	-	expression tag
Glu 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag
His 644	-	expression tag
His 645	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67801.9
Non-Polymers*	Number of molecules	3
	Total formula weight	1159.3
All*	Total formula weight	68961.2

*Water molecules are not included.