8XPO
Cryo-EM structure of Lassa virus RdRP elongation complex with the NTP form of compound HNC-1664 bound in the active site
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | RNA-directed RNA polymerase L | polymer | 2231 | 255200.4 | 1 | UniProt (Q6Y630) | Lassa virus Josiah | Protein L,Large structural protein,Replicase,Transcriptase |
| 2 | B (A) | RNA (14-MER) | polymer | 14 | 4516.8 | 1 | synthetic construct | ||
| 3 | C (T) | RNA (32-MER) | polymer | 32 | 10374.3 | 1 | synthetic construct | ||
| 4 | D (P) | RNA (9-MER) | polymer | 9 | 2808.7 | 1 | synthetic construct | ||
| 5 | E (L) | [[(2~{R},3~{R},4~{S},5~{R})-4-fluoranyl-5-(5-iodanyl-4-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 633.1 | 1 | Chemie (A1LVZ) |
Sequence modifications
L: 1 - 2220 (UniProt: Q6Y630)
| PDB | External Database | Details |
|---|---|---|
| Ser 2221 | - | expression tag |
| Ala 2222 | - | expression tag |
| Ser 2223 | - | expression tag |
| Asn 2224 | - | expression tag |
| Ser 2225 | - | expression tag |
| Leu 2226 | - | expression tag |
| Glu 2227 | - | expression tag |
| Val 2228 | - | expression tag |
| Leu 2229 | - | expression tag |
| Phe 2230 | - | expression tag |
| Gln 2231 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 272900.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 633.1 | |
| All* | Total formula weight | 273533.3 |
