8XP3
Cryo-EM structure of the human 40S ribosome with LARP1 and LRRC47
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (Ln) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | HG12,Large ribosomal subunit protein eL41 |
| 2 | B (S2) | 18S rRNA | polymer | 1869 | 602752.9 | 1 | GenBank (36162) | Homo sapiens (human) | |
| 3 | C (SA) | 40S ribosomal protein SA | polymer | 295 | 32883.9 | 1 | UniProt (P08865) Pfam (PF00318) Pfam (PF16122) | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 4 | D (SB) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 5 | E (SD) | 40S ribosomal protein S3 | polymer | 243 | 26729.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (human) | Small ribosomal subunit protein uS3 |
| 6 | F (SE) | 40S ribosomal protein S4, X isoform | polymer | 263 | 29654.9 | 1 | UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (human) | SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4 |
| 7 | G (SF) | 40S ribosomal protein S5 | polymer | 204 | 22913.5 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (human) | Small ribosomal subunit protein uS7 |
| 8 | H (SH) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (human) | Small ribosomal subunit protein eS7 |
| 9 | I (SI) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (human) | Small ribosomal subunit protein eS8 |
| 10 | J (SK) | 40S ribosomal protein S10 | polymer | 165 | 18933.8 | 1 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (human) | Small ribosomal subunit protein eS10 |
| 11 | K (SL) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (human) | Small ribosomal subunit protein uS17 |
| 12 | L (SP) | 40S ribosomal protein S15 | polymer | 145 | 17076.2 | 1 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (human) | RIG protein,Small ribosomal subunit protein uS19 |
| 13 | M (SQ) | 40S ribosomal protein S16 | polymer | 146 | 16477.4 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (human) | Small ribosomal subunit protein uS9 |
| 14 | N (SR) | 40S ribosomal protein S17 | polymer | 135 | 15578.2 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (human) | Small ribosomal subunit protein eS17 |
| 15 | O (SS) | 40S ribosomal protein S18 | polymer | 152 | 17759.8 | 1 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
| 16 | P (ST) | 40S ribosomal protein S19 | polymer | 145 | 16091.6 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (human) | Small ribosomal subunit protein eS19 |
| 17 | Q (SU) | 40S ribosomal protein S20 | polymer | 119 | 13398.8 | 1 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (human) | Small ribosomal subunit protein uS10 |
| 18 | R (SV) | 40S ribosomal protein S21 | polymer | 83 | 9124.4 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (human) | Small ribosomal subunit protein eS21 |
| 19 | S (SX) | 40S ribosomal protein S23 | polymer | 143 | 15844.7 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (human) | Small ribosomal subunit protein uS12 |
| 20 | T (Sa) | 40S ribosomal protein S26 | polymer | 115 | 13047.5 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (human) | Small ribosomal subunit protein eS26 |
| 21 | U (Sc) | 40S ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (human) | Small ribosomal subunit protein eS28 |
| 22 | V (Sd) | 40S ribosomal protein S29 | polymer | 56 | 6690.8 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (human) | Small ribosomal subunit protein uS14 |
| 23 | W (Sg) | Receptor of activated protein C kinase 1 | polymer | 317 | 35115.7 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 24 | X (SC) | 40S ribosomal protein S2 | polymer | 293 | 31376.5 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 25 | Y (SG) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 26 | Z (SJ) | 40S ribosomal protein S9 | polymer | 194 | 22641.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (human) | Small ribosomal subunit protein uS4 |
| 27 | AA (SM) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (human) | Small ribosomal subunit protein eS12 |
| 28 | BA (SN) | 40S ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (human) | Small ribosomal subunit protein uS15 |
| 29 | CA (SO) | 40S ribosomal protein S14 | polymer | 151 | 16302.8 | 1 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (human) | Small ribosomal subunit protein uS11 |
| 30 | DA (SW) | 40S ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (human) | Small ribosomal subunit protein uS8 |
| 31 | EA (SY) | 40S ribosomal protein S24 | polymer | 133 | 15463.3 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (human) | Small ribosomal subunit protein eS24 |
| 32 | FA (SZ) | 40S ribosomal protein S25 | polymer | 125 | 13776.2 | 1 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (human) | Small ribosomal subunit protein eS25 |
| 33 | GA (Sb) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 34 | HA (Se) | 40S ribosomal protein S30 | polymer | 59 | 6668.9 | 1 | UniProt (P62861) Pfam (PF04758) | Homo sapiens (human) | Small ribosomal subunit protein eS30 |
| 35 | IA (Sf) | Ubiquitin-40S ribosomal protein S27a | polymer | 156 | 18004.0 | 1 | UniProt (P62979) Pfam (PF00240) Pfam (PF01599) | Homo sapiens (human) | Ubiquitin carboxyl extension protein 80 |
| 36 | JA (JD) | La-related protein 1 | polymer | 1096 | 123705.3 | 1 | UniProt (Q6PKG0) Pfam (PF05383) Pfam (PF21071) | Homo sapiens (human) | La ribonucleoprotein domain family member 1 |
| 37 | KA (JC) | Leucine-rich repeat-containing protein 47 | polymer | 583 | 63563.9 | 1 | UniProt (Q8N1G4) Pfam (PF13855) Pfam (PF00560) | Homo sapiens (human) | |
| 38 | LA, MA, NA, OA (Sa, Sd, Sb, Sf) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
S2: 1 - 1869 (GenBank: 36162)
| PDB | External Database | Details |
|---|---|---|
| C 582 | U 582 | conflict |
| C 583 | A 583 | conflict |
| G 584 | A 584 | conflict |
| A 798 | G 798 | conflict |
| U 1095 | C 1095 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 37 |
| Total formula weight | 1412703.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 1412965.3 |
