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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8XOS

Cryo-EM structure of the tethered agonist-bound human PAR1-Gi complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35340313.91UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37941332.11UniProt (P54311)
Pfam (PF25391)		RattusTransducin beta chain 1
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer677432.61UniProt (P63212)
Pfam (PF00631)		Bos taurus (domestic cattle)G gamma-I
4D
(E)		scFv16polymer37540523.31Mus musculus
5E
(R)		Proteinase-activated receptor 1 LgBiTpolymer53258787.51UniProt (P25116)
Pfam (PF00001)		Homo sapiens (human)PAR-1,Coagulation factor II receptor,Thrombin receptor
6F, G
(R)		CHOLESTEROLnon-polymer386.72Chemie (CLR)
Sequence modifications
A: 2 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Ala 203Gly 203engineered mutation
Ser 326Ala 326engineered mutation
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -30-initiating methionine
Val -29-expression tag
Ser -28-expression tag
Gly -27-expression tag
Trp -26-expression tag
Arg -25-expression tag
Leu -24-expression tag
Phe -23-expression tag
Lys -22-expression tag
Lys -21-expression tag
Ile -20-expression tag
Ser -19-expression tag
Gly -18-expression tag
Ser -17-expression tag
Ser -16-expression tag
Gly -15-expression tag
Gly -14-expression tag
Gly -13-expression tag
Gly -12-expression tag
Ser -11-expression tag
Gly -10-expression tag
Gly -9-expression tag
Gly -8-expression tag
Gly -7-expression tag
Ser -6-expression tag
Ser -5-expression tag
Gly -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
His 341-expression tag
His 342-expression tag
His 343-expression tag
His 344-expression tag
His 345-expression tag
His 346-expression tag
His 347-expression tag
His 348-expression tag
R: 42 - 397 (UniProt: P25116)
PDBExternal DatabaseDetails
Gly 398-expression tag
Ser 399-expression tag
Ser 400-expression tag
Gly 401-expression tag
Gly 402-expression tag
Gly 403-expression tag
Gly 404-expression tag
Ser 405-expression tag
Gly 406-expression tag
Gly 407-expression tag
Gly 408-expression tag
Gly 409-expression tag
Ser 410-expression tag
Ser 411-expression tag
Gly 412-expression tag
Val 413-expression tag
Phe 414-expression tag
Thr 415-expression tag
Leu 416-expression tag
Glu 417-expression tag
Asp 418-expression tag
Phe 419-expression tag
Val 420-expression tag
Gly 421-expression tag
Asp 422-expression tag
Trp 423-expression tag
Glu 424-expression tag
Gln 425-expression tag
Thr 426-expression tag
Ala 427-expression tag
Ala 428-expression tag
Tyr 429-expression tag
Asn 430-expression tag
Leu 431-expression tag
Asp 432-expression tag
Gln 433-expression tag
Val 434-expression tag
Leu 435-expression tag
Glu 436-expression tag
Gln 437-expression tag
Gly 438-expression tag
Gly 439-expression tag
Val 440-expression tag
Ser 441-expression tag
Ser 442-expression tag
Leu 443-expression tag
Leu 444-expression tag
Gln 445-expression tag
Asn 446-expression tag
Leu 447-expression tag
Ala 448-expression tag
Val 449-expression tag
Ser 450-expression tag
Val 451-expression tag
Thr 452-expression tag
Pro 453-expression tag
Ile 454-expression tag
Gln 455-expression tag
Arg 456-expression tag
Ile 457-expression tag
Val 458-expression tag
Arg 459-expression tag
Ser 460-expression tag
Gly 461-expression tag
Glu 462-expression tag
Asn 463-expression tag
Ala 464-expression tag
Leu 465-expression tag
Lys 466-expression tag
Ile 467-expression tag
Asp 468-expression tag
Ile 469-expression tag
His 470-expression tag
Val 471-expression tag
Ile 472-expression tag
Ile 473-expression tag
Pro 474-expression tag
Tyr 475-expression tag
Glu 476-expression tag
Gly 477-expression tag
Leu 478-expression tag
Ser 479-expression tag
Ala 480-expression tag
Asp 481-expression tag
Gln 482-expression tag
Met 483-expression tag
Ala 484-expression tag
Gln 485-expression tag
Ile 486-expression tag
Glu 487-expression tag
Glu 488-expression tag
Val 489-expression tag
Phe 490-expression tag
Lys 491-expression tag
Val 492-expression tag
Val 493-expression tag
Tyr 494-expression tag
Pro 495-expression tag
Val 496-expression tag
Asp 497-expression tag
Asp 498-expression tag
His 499-expression tag
His 500-expression tag
Phe 501-expression tag
Lys 502-expression tag
Val 503-expression tag
Ile 504-expression tag
Leu 505-expression tag
Pro 506-expression tag
Tyr 507-expression tag
Gly 508-expression tag
Thr 509-expression tag
Leu 510-expression tag
Val 511-expression tag
Ile 512-expression tag
Asp 513-expression tag
Gly 514-expression tag
Val 515-expression tag
Thr 516-expression tag
Pro 517-expression tag
Asn 518-expression tag
Met 519-expression tag
Leu 520-expression tag
Asn 521-expression tag
Tyr 522-expression tag
Phe 523-expression tag
Gly 524-expression tag
Arg 525-expression tag
Pro 526-expression tag
Tyr 527-expression tag
Glu 528-expression tag
Gly 529-expression tag
Ile 530-expression tag
Ala 531-expression tag
Val 532-expression tag
Phe 533-expression tag
Asp 534-expression tag
Gly 535-expression tag
Lys 536-expression tag
Lys 537-expression tag
Ile 538-expression tag
Thr 539-expression tag
Val 540-expression tag
Thr 541-expression tag
Gly 542-expression tag
Thr 543-expression tag
Leu 544-expression tag
Trp 545-expression tag
Asn 546-expression tag
Gly 547-expression tag
Asn 548-expression tag
Lys 549-expression tag
Ile 550-expression tag
Ile 551-expression tag
Asp 552-expression tag
Glu 553-expression tag
Arg 554-expression tag
Leu 555-expression tag
Ile 556-expression tag
Thr 557-expression tag
Pro 558-expression tag
Asp 559-expression tag
Gly 560-expression tag
Ser 561-expression tag
Met 562-expression tag
Leu 563-expression tag
Phe 564-expression tag
Arg 565-expression tag
Val 566-expression tag
Thr 567-expression tag
Ile 568-expression tag
Asn 569-expression tag
Ser 570-expression tag
Gly 571-expression tag
Gly 572-expression tag
Ser 573-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight188389.4
Non-Polymers*Number of molecules2
Total formula weight773.3
All*Total formula weight189162.7
*Water molecules are not included.

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PDB entries from 2026-01-14

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